Disease course of ulcerative proctitis in children: A population-based study on behalf of the SIGENP IBD Group.

Autor: Martinelli M; Department of Translational Medical Science, Section of Pediatrics, University of Naples 'Federico II', Via S. Pansini, 5, Naples 80131, Italy., Fedele F; Department of Translational Medical Science, Section of Pediatrics, University of Naples 'Federico II', Via S. Pansini, 5, Naples 80131, Italy., Romano C; Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Messina, Italy., Aloi M; Women's and Children's Health Department, Pediatric Gastroenterology and Hepatology Unit, Sapienza University of Rome, Rome, Italy., Lionetti P; University of Florence-Meyer Hospital, Florence, Italy., Alvisi P; Pediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy., Arrigo S; Pediatric Gastroenterology and Endoscopy Unit, Institute 'Giannina Gaslini', Genoa, Italy., Bosa L; Department of Women's and Children's Health, Unit of Pediatric Gastroenterology Digestive Endoscopy, Hepatology and Care of the Child With Liver Transplantation, Padua, Italy., Bramuzzo M; Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy., D'Arcangelo G; Women's and Children's Health Department, Pediatric Gastroenterology and Hepatology Unit, Sapienza University of Rome, Rome, Italy., Dipasquale V; Pediatric Gastroenterology and Cystic Fibrosis Unit, University of Messina, Messina, Italy., Felici E; Pediatric and Pediatric Emergency Unit, 'Umberto Bosio' Center for Digestive Diseases, The Children Hospital, AO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy., Fuoti M; Pediatric Gastroenterology and GI Endoscopy, University Department of Pediatrics, Children's Hospital, Spedali Civili, Brescia, Italy., Gatti S; Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy., Graziano F; Villa Sofia Cervello Hospital, Pediatric Unit, Palermo, Italy., Illiceto MT; Santo Spirito Hospital, Pediatric Gastroenterology and Endoscopic Unit- Department of Pediatrics, Pescara, Italy., Labriola F; Pediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy., Norsa L; Paediatric Hepatology Gastroenterology and Transplantation, Papa Giovanni XXIII Hospital, Bergamo, Italy., Pastore M; Fondazione IRCCS Casa Sollievo della Sofferenza, Division of Pediatrics, San Giovanni Rotondo, Italy., Scarallo L; University of Florence-Meyer Hospital, Florence, Italy., Strisciuglio C; Department of Woman, Child and General and Specialistic Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy., Zuin G; Department of Pediatrics, University of Milano-Bicocca, Foundation MBBM/San Gerardo Hospital, Monza, Italy., Miele E; Department of Translational Medical Science, Section of Pediatrics, University of Naples 'Federico II', Via S. Pansini, 5, Naples 80131, Italy. Electronic address: erasmo.miele@unina.it., Staiano A; Department of Translational Medical Science, Section of Pediatrics, University of Naples 'Federico II', Via S. Pansini, 5, Naples 80131, Italy.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2024 Jan; Vol. 56 (1), pp. 70-76. Date of Electronic Publication: 2023 Jul 21.
DOI: 10.1016/j.dld.2023.07.008
Abstrakt: Background: The natural history of ulcerative proctitis (UP) has been poorly investigated in children.
Aims: We aimed to compare the disease course of children with UP at diagnosis to the other locations and to identify extension predictors.
Methods: This was a multicenter, observational study carried out from data prospectively entered in the SIGENP-IBD-Registry. Children with ulcerative colitis (UC) diagnosis and at least 1-year follow-up were included. On the basis of Paris classification UP patients were identified and compared with the other locations.
Results: 872 children were enrolled (median age at diagnosis: 11.2 years; M/F: 426/446), of whom 78 (9%) with UP. Kaplan-Meier analysis demonstrated increased cumulative probabilities of disease extension in the E1 group [1 year: 20.3%; 5 years: 52.7%; 10 years: 72.4%] compared to E3 group [1 year: 8.5%; 5 years: 24.9% and 10 years: 60.1%, p=0.001]. No differences were observed comparing E1 and E2 groups [p=0.4]. Cumulative probabilities of surgery at 1, 5 and 10 years were 1.3, 2.8 and 2.8% in the E1 group and 2.5, 8 and 12.8% in the E2-E3-E4 group, respectively (p=0.1). Cox regression analysis demonstrated that PUCAI>35 at diagnosis was associated with endoscopic extension (HR=4.9; CI 95% 1.5-15.2, p=0.006).
Conclusions: UP is associated with similar short and long-term outcomes compared to other locations.
Competing Interests: Conflict of interest The authors have no conflict of interests to declare with regards to this manuscript.
(Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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