Commensal fungi in intestinal health and disease.

Autor: Ost KS; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO, USA. kyla.ost@cuanschutz.edu., Round JL; Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, USA. june.round@path.utah.edu.; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. june.round@path.utah.edu.
Jazyk: angličtina
Zdroj: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2023 Nov; Vol. 20 (11), pp. 723-734. Date of Electronic Publication: 2023 Jul 21.
DOI: 10.1038/s41575-023-00816-w
Abstrakt: The microbiota is known to influence several facets of mammalian development, digestion and disease. Most studies of the microbiota have focused on the bacterial component, but the importance of commensal fungi in health and disease is becoming increasingly clear. Although fungi account for a smaller proportion of the microbiota than bacteria by number, they are much larger and therefore account for a substantial proportion of the biomass. Moreover, as fungi are eukaryotes, their metabolic pathways are complex and unique. In this Review, we discuss the evidence for involvement of specific members of the mycobiota in intestinal diseases, including inflammatory bowel disease, colorectal cancer and pancreatic cancer. We also highlight the importance of fungal interactions with intestinal bacteria and with the immune system. Although most studies of commensal fungi have focused on their role in disease, we also consider the beneficial effects of fungal colonies in the gut. The evidence highlights potential opportunities to target fungi and their interactions for therapeutic purposes.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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