Concentration of low-density lipoproteins (LDL) is significantly reduced after nilotinib discontinuation.

Autor: Roa-Chamorro R; Vascular Risk Unit, Internal Medicine, Virgen de Las Nieves Hospital, Avenida de Las Fuerzas Armadas 2, 18014, Granada, Spain. ricardoroa@gmail.com., Puerta-Puerta JM; Hematology, Virgen de Las Nieves Hospital, Granada, Spain., Torres-Quintero L; Cardiology, Virgen de Las Nieves Hospital, Granada, Spain., Jaén-Águila F; Vascular Risk Unit, Internal Medicine, Virgen de Las Nieves Hospital, Avenida de Las Fuerzas Armadas 2, 18014, Granada, Spain., González-Bustos P; Vascular Risk Unit, Internal Medicine, Virgen de Las Nieves Hospital, Avenida de Las Fuerzas Armadas 2, 18014, Granada, Spain., Rodríguez-Gil MÁ; Hematology, Virgen de Las Nieves Hospital, Granada, Spain., Mediavilla-García JD; Vascular Risk Unit, Internal Medicine, Virgen de Las Nieves Hospital, Avenida de Las Fuerzas Armadas 2, 18014, Granada, Spain.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jul 21; Vol. 13 (1), pp. 11781. Date of Electronic Publication: 2023 Jul 21.
DOI: 10.1038/s41598-023-39057-x
Abstrakt: Dyslipidemia is a frequent side effect associated with nilotinib treatment. Patients with chronic myeloid leukemia (CML) under treatment with nilotinib who develop dyslipidemia have been shown to have a higher risk of presenting atherosclerotic cardiovascular disease (ACVD). Therapeutic discontinuation in selected individuals could be a strategy in order to prevent the development of ACVD. Observational study of patients with CML under nilotinib treatment. The lipid values were gathered before starting with nilotinib and after 3 months. Such values were also measured before discontinuation in patients who suspended nilotinib treatment, as well as 3 and 12 months later. 32 patients were included, 19 of them treated in monotherapy with nilotinib. The concentrations of total cholesterol and low-density lipoproteins (LDL) increased significantly after 3 months of treatment (27.29 mg/dL ± 22.88, p < 0.01). Of the total number of patients treated, 12 discontinued the treatment. LDL concentration was significantly reduced after 3 months of the nilotinib discontinuation (- 27.58 mg/dL ± 38.30, p = 0.030), remaining substantially lower after 12 months, compared to the time previous to discontinuation (- 24.58 mg/dL ± 37.31, p = 0.043). Nilotinib suspension reduces significantly LDL concentrations. These data support the strategy of therapeutic discontinuation in order to prevent future cardiovascular complications, especially in patients with prior cardiovascular risk factors.
(© 2023. The Author(s).)
Databáze: MEDLINE
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