Unveiling the intricacies of intracellular Ca 2+ regulation in the heart.
| Autor: | Smith CER; Department of Pharmacology, University of California Davis, Davis, California. Electronic address: cersmith@ucdavis.edu., Grandi E; Department of Pharmacology, University of California Davis, Davis, California. Electronic address: ele.grandi@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Biophysical journal [Biophys J] 2023 Aug 08; Vol. 122 (15), pp. 3019-3021. Date of Electronic Publication: 2023 Jul 20. |
| DOI: | 10.1016/j.bpj.2023.07.005 |
| Abstrakt: | Recent studies have provided valuable insight into the key mechanisms contributing to the spatiotemporal regulation of intracellular Ca 2+ release and Ca 2+ signaling in the heart. In this research highlight, we focus on the latest findings published in Biophysical Journal examining the structural organization of Ca 2+ handling proteins and assessing the functional aspects of intracellular Ca 2+ regulation in health and the detrimental consequences of Ca 2+ dysregulation in disease. These important studies pave the way for future mechanistic investigations and multiscale understanding of Ca 2+ signaling in the heart. (Copyright © 2023 Biophysical Society. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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