Nutritional Composition and Pharmacological Activity of Musa balbisiana Colla Seed: An Insight into Phytochemical and Cellular Bioenergetic Profiling.

Autor: Gurumayum N; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India.; Department of Zoology, Gauhati University, Guwahati, 781014, India., Sarma PP; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India., Khound P; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India.; Department of Zoology, Gauhati University, Guwahati, 781014, India., Jana UK; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India.; Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, 700064, India., Devi R; Life Sciences Division, Institute of Advanced Study in Science and Technology (IASST), Guwahati, 781035, Assam, India. rajlakshmi@iasst.gov.in.; Department of Zoology, Gauhati University, Guwahati, 781014, India. rajlakshmi@iasst.gov.in.
Jazyk: angličtina
Zdroj: Plant foods for human nutrition (Dordrecht, Netherlands) [Plant Foods Hum Nutr] 2023 Sep; Vol. 78 (3), pp. 520-525. Date of Electronic Publication: 2023 Jul 21.
DOI: 10.1007/s11130-023-01080-8
Abstrakt: Musa balbisiana Colla belongs to the family Musaceae which is well-known for its nutritional and pharmacological properties. Here, we have analysed the phytochemical content and evaluated the nutritional, antioxidant, anti-glycation, α-amylase, and α-glucosidase inhibition potential. Moreover, for the first time, we have studied the bioenergetic profiles of the bioactive fractions of M. balbisiana seeds extract against oxidative stress-related mitochondrial and cellular dysfunction using XFe24 extracellular flux analyzer. M. balbisiana seeds have high nutritional values with significant levels of carbohydrates, starch, protein, and minerals (Ca, Na, Mg, Cu, Fe, and Zn). Bioactivity-guided fractionation of the methanolic extract of M. balbisiana seeds revealed that the ethyl acetate fraction (EAF) showed the highest antioxidant, anti-glycation, and phytochemical content as compared to other fractions. Moreover, the EAF showed a lower α-amylase inhibition and a higher α-glucosidase inhibitory activity. Most importantly, our GC-MS analyses of EAF revealed the presence of unique and previously unreported 14 phytochemical compounds. A strong correlation between the biological activities and total phenolic/tannin content was observed. In addition, the bioactive fraction of M. balbisiana seeds (EAF) improved the bioenergetic profiles of free fatty acid-induced oxidative stress with a concomitant increase in ATP production, and respiratory and glycolytic capacity. Altogether, our findings suggest that M. balbisiana seeds can be used as a natural supplement to boost antioxidant levels and combat oxidative stress and non-enzymatic glycation.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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