| Autor: |
Garro MF; Area de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina., Gil RA; Instituto de Química de San Luis, INQUISAL-CONICET-UNSL, San Luis, Argentina., Leporati J; Facultad de Ingeniería y Ciencias agropecuarias FICA-UNSL, San Luis, Argentina., Garro HA; Area de Quíımica Orgánica, INTEQUI-CONICET-UNSL, San Luis, Argentina.; Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC,), Universidad Nacional de Rosario, Rosario, Argentina. |
| Abstrakt: |
Euphorbia serpens has been used in central-west region of Argentina in traditional medicine as diuretic plant. The aim of this present study was to evaluate the diuretic activity of E. serpens in-vivo. We used dried aerial parts, and infusions from these were orally administered to Wistar rats. Its effect was evaluated using furosemide as a positive drug and isotonic salt solution as negative control. Their urine output was quantified at several time intervals. The volume of urine excreted and Na + increased significantly, being similar to furosemide. Mannitol, was the main component in aqueous extracts of E. serpens, and the acetone extract showed the presence of Δ 12 - oleanane-type triterpenoids compounds, mainly hederagenin. No toxic effects were observed. |
