Cervical Health in Systemic Lupus Erythematosus.

Autor:	Dhar JP; Department of Internal Medicine/Rheumatology, Wayne State University School of Medicine, Detroit, Michigan, USA.; Rheumatology Fellowship Program, Department of Internal Medicine/Rheumatology, Ascension St. John Hospital, Detroit, Michigan, USA., Walline H; Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA., Mor G; C.S. Mott Center for Human Growth and Development, Detroit, Michigan, USA.; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.; Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, USA.; Department of Microbiology and Immunology, Wayne State University School of Medicine, Detroit, Michigan, USA., Fathallah L; Ascension St. John Hospital, Detroit, Michigan, USA., Szpunar S; Central Michigan University, Mount Pleasant, Michigan, USA.; Biomedical Investigations and Research, Ascension St. John Hospital, Detroit, Michigan, USA., Saravolatz L; Ascension St. John Hospital, Detroit, Michigan, USA.; Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA., Carey T; Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jazyk:	angličtina
Zdroj:	Women's health reports (New Rochelle, N.Y.) [Womens Health Rep (New Rochelle)] 2023 Jul 12; Vol. 4 (1), pp. 328-337. Date of Electronic Publication: 2023 Jul 12 (Print Publication: 2023).
DOI:	10.1089/whr.2023.0023
Abstrakt:	Objective: A health disparity exists for African American (AA) women with systemic lupus erythematosus (SLE) who have increased prevalence of human papilloma virus (HPV) infection and cervical neoplasia. We used a self-sampling brush to obtain cervical cells to assess cytology, HPV infection, and vaginal cytokine production in AA women with SLE. Methods: Thirty AA women with SLE ages 18-50 years consented to participate. Clinical information was obtained by review of records and patient interviews, and surveys administered to assess cervical health history, knowledge of HPV, and satisfaction with the self-sampling brush. Vaginal samples were analyzed for cytology, HPV DNA and RNA, and vaginal cytokine RNA. Results: Our cohort (mean 36.9, ±9.4 years) had moderate/severe SLE and were on immunosuppressives. The majority had history of abnormal pap smears (63%) with prevalent risk factors for HPV infection: multiple sex partners (9.5 ± 7), not vaccinated for HPV (83.3%), smoking (26.7%), and not using condoms (73.3%). Most were aware of HPV causing cervical cancer (70%) but were unaware of other HPV-related diseases. Most preferred self-sampling over traditional pap smear (80%). Abnormal cytology was detected in 13.3%. HPV DNA was detected in 70%, with half showing multiple types, and all showing active infection (+RNA). HPV-infected samples demonstrated RNA expression of multiple cytokines with no specific/ consistent pattern. Conclusion: Our high-risk cohort lacked knowledge about HPV-related diseases and were not employing strategies to reduce their risk with vaccination and condoms. This study highlights the need for cervical health education, increased monitoring, and intervention in these high-risk women. Competing Interests: No competing financial interests exist. (© J. Patricia Dhar et al., 2023; Published by Mary Ann Liebert, Inc.)
Databáze:	MEDLINE
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