An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage.

Autor: Agrez M; InterK Peptide Therapeutics Limited, Sydney, NSW, Australia. michael.agrez@interk.com.au.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia. michael.agrez@interk.com.au., Rybchyn MS; School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, Australia., De Silva WGM; School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, Australia., Mason RS; School of Medical Sciences and Bosch Institute, University of Sydney, Sydney, Australia.; Charles Perkins Centre and School of Life and Environmental Sciences, University of Sydney, Sydney, Australia., Chandler C; Auspep Pty Limited, Melbourne, Australia., Piva TJ; Health and Biomedical Sciences, RMIT University, Melbourne, Australia., Thurecht K; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia., Fletcher N; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia., Liu F; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia., Subramaniam G; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia., Howard CB; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.; Australian Institute for Bioengineering and Nanotechnology and the ARC Training Centre for Innovation in Biomedical Imaging Technologies, University of Queensland, Brisbane, Australia., Blyth B; Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology at the University of Melbourne, Melbourne, Australia., Parker S; InterK Peptide Therapeutics Limited, Sydney, NSW, Australia., Turner D; Concept Life Sciences Limited, Edinburgh, Scotland., Rzepecka J; Concept Life Sciences Limited, Edinburgh, Scotland., Knox G; Concept Life Sciences Limited, Edinburgh, Scotland., Nika A; Concept Life Sciences Limited, Edinburgh, Scotland., Hall A; Concept Life Sciences Limited, Edinburgh, Scotland., Gooding H; Concept Life Sciences Limited, Edinburgh, Scotland., Gallagher L; Concept Life Sciences Limited, Edinburgh, Scotland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jul 20; Vol. 13 (1), pp. 11702. Date of Electronic Publication: 2023 Jul 20.
DOI: 10.1038/s41598-023-38890-4
Abstrakt: Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated upon UVR-induced DNA damage, is linked to expression of interleukin-12 (IL-12) which serves to limit immunosuppression and augment the DNA repair process. Herein, we report an immunomodulating peptide, designated IK14800, that not only elicits secretion of IL-12, interleukin-2 (IL-2) and interferon-gamma (IFN-γ) but also reduces DNA damage in the skin following exposure to UVR. Combined with re-invigoration of exhausted CD4+ T cells, inhibition of UVR-induced MMP-1 release and suppression of B16F10 melanoma metastases, IK14800 offers an opportunity to gain further insight into mechanisms underlying the development and progression of skin cancers.
(© 2023. The Author(s).)
Databáze: MEDLINE
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