Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study.

Autor: Singh M; Indian Council of Medical Research (ICMR), New Delhi, India., Dhingra B; Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhopal, MP, India., Bishnu B; National TB Elimination Program, World Health Organization - West Bengal, Kolkata, India., Pandey D; Department of Community Medicine, Government Medical College, Ratlam, MP, India., Anand PK; Indian Council of Medical Research, National Institute for Implementation Research on Non-communicable Diseases (formerly Desert Medicine Research Centre), Jodhpur, Rajasthan, India., Gupta S; Department of Pediatrics, King George Medical University, Lucknow, UP, India., Das VR; Rajendra Memorial Research Institute of Medical Sciences, Indian Council of Medical Research (ICMR), Patna, India., Dhochak N; Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India., Kabra SK; Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India. skkabra@hotmail.com.
Jazyk: angličtina
Zdroj: Indian journal of pediatrics [Indian J Pediatr] 2024 Aug; Vol. 91 (8), pp. 773-780. Date of Electronic Publication: 2023 Jul 20.
DOI: 10.1007/s12098-023-04723-5
Abstrakt: Objectives: To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers.
Methods: A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis.
Results: A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family.
Conclusions: The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.
(© 2023. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.)
Databáze: MEDLINE
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