Can affinity of hemoglobin to oxygen to be a prognostic marker in critically ill COVID-19 patients?
| Autor: | Alay GH; Intensive Care Unit, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey., Tatlisuluoglu D; Intensive Care Unit, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey., Turan G; Intensive Care Unit, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey. |
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| Jazyk: | angličtina |
| Zdroj: | Nigerian journal of clinical practice [Niger J Clin Pract] 2023 Jun; Vol. 26 (6), pp. 731-736. |
| DOI: | 10.4103/njcp.njcp_581_22 |
| Abstrakt: | Background: This study's objective is to determine the slope of the hemoglobin oxygen dissociation curve in critically ill patients who have COVID-19 along with blood gas measurements and how mortality might be impacted by this circumstance. Aim: It has been reported that the hemoglobin oxygen dissociation curve is not different from healthy patients in COVID-19. However, there are insufficient data on the behavior of the curve in patients who require intensive care. Patients and Methods: This retrospective study was conducted between 01.03.2021 and 01.07.2021 with patients who were followed up due to COVID-19 in adult intensive care unit. P50 and lactate value obtained from in vitro calculated blood gas analysis. The survival status of the patients was recorded. Results: The mean P50 value at the admission of nonsurvivors was significantly higher than survivors. In correlation analysis, a significant positive correlation was seen between P50, mortality, and lactate level at admission. SpO Conclusion: A right shift in the hemoglobin oxygen dissociation curve is associated with mortality. Lactate levels were also associated with a right shift. Prospective experimental studies are needed to provide a better understanding of this process. Competing Interests: None |
| Databáze: | MEDLINE |
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