Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease.

Autor:	Cebull HL; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA 30322., Aremu OO; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Observatory7925, South Africa., Kulkarni RS; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907., Zhang SX; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907., Samuels P; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory 7925, South Africa., Jermy S; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Observatory 7925, South Africa., Ntusi NAB; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Cape Universities Body Imaging Centre, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa; Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town and Groote Schuur Hospital, Observatory 7925, South Africa; South African Medical Research Council Extramural Unit on the Intersection of Noncommunicable Diseases and Infectious Diseases, Cape Town 7925, South Africa., Goergen CJ; Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907; Indiana University School of Medicine, Indianapolis, IN 46202.
Jazyk:	angličtina
Zdroj:	Journal of biomechanical engineering [J Biomech Eng] 2023 Nov 01; Vol. 145 (11).
DOI:	10.1115/1.4063000
Abstrakt:	Rheumatic heart disease (RHD) is a neglected tropical disease despite the substantial global health burden. In this study, we aimed to develop a lower cost method of modeling aortic blood flow using subject-specific velocity profiles, aiding our understanding of RHD's consequences on the structure and function of the ascending aorta. Echocardiography and cardiovascular magnetic resonance (CMR) are often used for diagnosis, including valve dysfunction assessments. However, there is a need to further characterize aortic valve lesions to improve treatment options and timing for patients, while using accessible and affordable imaging strategies. Here, we simulated effects of RHD aortic valve lesions on the aorta using computational fluid dynamics (CFD). We hypothesized that inlet velocity distribution and wall shear stress (WSS) will differ between RHD and non-RHD individuals, as well as between subject-specific and standard Womersley velocity profiles. Phase-contrast CMR data from South Africa of six RHD subjects with aortic stenosis and/or regurgitation and six matched controls were used to estimate subject-specific velocity inlet profiles and the mean velocity for Womersley profiles. Our findings were twofold. First, we found WSS in subject-specific RHD was significantly higher (p < 0.05) than control subject simulations, while Womersley simulation groups did not differ. Second, evaluating spatial velocity differences (ΔSV) between simulation types revealed that simulations of RHD had significantly higher ΔSV than non-RHD (p < 0.05), these results highlight the need for implementing subject-specific input into RHD CFD, which we demonstrate how to accomplish through accessible methods. (Copyright © 2023 by ASME.)
Databáze:	MEDLINE
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