Central Retinal Artery Occlusion in COVID-Associated Mucormycosis.

Autor:	Srivastava SR; Department of Ophthalmology, IPGME and R and SSKMH, Kolkata, West Bengal, India., Sarkar P; Department of Neurology, Bangur Institute of Neurosciences, IPGME and R and SSKMH, Kolkata, West Bengal, India., Ganguly P; Division of Orbit and Oculoplasty, Regional Institute of Ophthalmology, Kolkata, West Bengal, India., Mukherjee D; Department of Neuromedicine, Bangur Institute of Neurosciences, IPGME and R and SSKMH, Kolkata, West Bengal, India., Ray BK; Department of Neuromedicine, Bangur Institute of Neurosciences, IPGME and R and SSKMH, Kolkata, West Bengal, India., Dubey S; Department of Neuromedicine, Bangur Institute of Neurosciences, IPGME and R and SSKMH, Kolkata, West Bengal, India., Pandit A; Department of Neuromedicine, Bangur Institute of Neurosciences, IPGME and R and SSKMH, Kolkata, West Bengal, India., Sengupta A; Department of Pulmonary Medicine, IPGME and R and SSKMH, Kolkata, West Bengal, India., Bandopadhyay M; Department of Anatomy, IPGME and R and SSKMH, Kolkata, West Bengal, India., Ghosh AK; Regional Institute of Ophthalmology, Kolkata, West Bengal, India., Poddar KG; Department of Histopathology, AMRI Hospital, Kolkata, West Bengal, India., Guha S; Department of Ophthalmology, IPGME and R and SSKMH, Kolkata, West Bengal, India., Ayub A; Regional Institute of Ophthalmology, Kolkata, West Bengal, India.
Jazyk:	angličtina
Zdroj:	Journal of global infectious diseases [J Glob Infect Dis] 2023 May 31; Vol. 15 (2), pp. 66-71. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).
DOI:	10.4103/jgid.jgid_185_22
Abstrakt:	Introduction: Significant surge of mucormycosis was reported in the Indian Subcontinent during the second wave of the COVID-19 pandemic. COVID-associated mucormycosis (CAM) was defined as the development of features of mucormycosis with prior or current history of COVID-19 infection. Rapid angioinvasion is an important characteristic of mucormycosis. Authors intended to find out the prevalence of retinal arterial occlusion and its association with vascular embolic occlusion elsewhere in the body among CAM patients in this study. Methods: This was an observational study. All consecutive-confirmed cases of mucormycosis ( n = 89) and age-/gender-/risk factor-matched controls ( n = 324) admitted in the designated COVID center were included in the study. All cases and controls underwent comprehensive ophthalmological, otorhinological, and neurological examinations. All necessary investigations to support the clinical diagnosis were done. Qualitative data were analyzed using the Chi-square test. Quantitative data for comparison of means between the cases and controls were done using unpaired t -test. Results: Twenty-one (23.59%) patients manifested the defined outcome of central retinal artery occlusion (CRAO). Among age-matched control, with similar diabetic status, none had developed the final outcome as defined ( P < 0.05). About 90.47% of subjects with CRAO presented with no perception of light vision. Thirteen subjects (61.9%) with the final outcome developed clinical manifestations of stroke during the course of their illness with radiological evidence of watershed infarction ( P = 0.001). Orbital debridement was performed in 9 (42.85%) subjects while orbital exenteration was done in 8 (38.09%) subjects. Conclusions: CRAO in CAM patients was found to have aggressive nature turning the eye blind in a very short period of time. CRAO can serve as a harbinger for subsequent development of more debilitating and life-threatening conditions such as stroke among CAM patients. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Journal of Global Infectious Diseases.)
Databáze:	MEDLINE
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