X-ray and MR Contrast Bearing Nanoparticles Enhance the Therapeutic Response of Image-Guided Radiation Therapy for Oral Cancer.

Autor:	Sharma G; Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India., Razeghi Kondelaji MH; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA., Sharma GP; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Hansen C; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA., Parchur AK; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Shafiee S; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA., Jagtap JM; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Fish B; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Bergom C; Department of Radiation Oncology, Washington University, St Louis, MO, USA., Paulson E; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Hall WA; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Himburg HA; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Joshi A; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA.
Jazyk:	angličtina
Zdroj:	Technology in cancer research & treatment [Technol Cancer Res Treat] 2023 Jan-Dec; Vol. 22, pp. 15330338231189593.
DOI:	10.1177/15330338231189593
Abstrakt:	Introduction: Radiation therapy for head and neck squamous cell carcinoma is constrained by radiotoxicity to normal tissue. We demonstrate 100 nm theranostic nanoparticles for image-guided radiation therapy planning and enhancement in rat head and neck squamous cell carcinoma models. Methods: PEG conjugated theranostic nanoparticles comprising of Au nanorods coated with Gadolinium oxide layers were tested for radiation therapy enhancement in 2D cultures of OSC-19-GFP-luc cells, and orthotopic tongue xenografts in male immunocompromised Salt sensitive or SS rats via both intratumoral and intravenous delivery. The radiation therapy enhancement mechanism was investigated. Results: Theranostic nanoparticles demonstrated both X-ray/magnetic resonance contrast in a dose-dependent manner. Magnetic resonance images depicted optimal tumor-to-background uptake at 4 h post injection. Theranostic nanoparticle + Radiation treated rats experienced reduced tumor growth compared to controls, and reduction in lung metastasis. Conclusions: Theranostic nanoparticles enable preprocedure radiotherapy planning, as well as enhance radiation treatment efficacy for head and neck tumors.
Databáze:	MEDLINE
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