Influence of interleukin-8 polymorphism on endometriosis-related pelvic pain.

Autor: Cardoso JV; Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Universidade do Estado do Rio de Janeiro (UERJ), RJ, Brazil., Machado DE; Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Universidade do Estado do Rio de Janeiro (UERJ), RJ, Brazil., da Silva MC; Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Universidade do Estado do Rio de Janeiro (UERJ), RJ, Brazil., de Mello MP; Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Universidade do Estado do Rio de Janeiro (UERJ), RJ, Brazil., Berardo PT; Serviço de Ginecologia, Hospital Federal dos Servidores do Estado (HFSE), Rio de Janeiro, Brazil., Medeiros R; Grupo de Oncologia Molecular e Patologia Viral, Centro de Investigação do Instituto Português de Oncologia do Porto (IPO Porto)/Dep. Patologia e Medicina Laboratorial, Patologia Clínica SV/ (Rede de Investigação em Saúde)/Porto, Centro Abrangente de Oncologia, Porto, Portugal., Perini JA; Laboratório de Pesquisa de Ciências Farmacêuticas (LAPESF), Universidade do Estado do Rio de Janeiro (UERJ), RJ, Brazil. Electronic address: jamilaperini@yahoo.com.br.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2023 Oct; Vol. 84 (10), pp. 561-566. Date of Electronic Publication: 2023 Jul 18.
DOI: 10.1016/j.humimm.2023.07.004
Abstrakt: Endometriosis presents a pro-inflammatory microenvironment influenced by cytokines, such as interleukin (IL)-8, which expression may be influenced by genetic polymorphisms. Therefore, we aimed to investigate the role of interleukin (IL)-8 rs4073 polymorphism in endometriosis' development and its related symptoms. A case-control study was conducted with 207 women with endometriosis and 193 healthy controls. Polymorphism was genotyped using a TaqMan validated assay. Associations were evaluated by binary logistic regression, using odds ratios (OR) and 95 % confidence intervals (CI), and P ≤ 0.05 was considered significant. Cases were younger (36 ± 6.8 versus 39 ± 8.4) and had lower body mass index (26.5 ± 5.3 versus 35.7 ± 6.3 Kg/m 2 ) than controls (P < 0.001). Higher prevalence of symptoms and infertility was observed in cases, compared to controls (P < 0.001). Minor allele frequencies of IL-8 rs4073 (T) were 42.3 % and 39.9 % for cases and controls, respectively, and no associations were found between IL and 8 rs4073 polymorphism and endometriosis' prevalence or staging. However, the polymorphism was associated with chronic pelvic pain among cases (OR = 0.54; 95 %CI = 0.29-0.98). The IL-8 rs4073A > T polymorphism may contribute to lower IL-8 expression and, consequently, decrease endometriosis-related pelvic pain. These findings can support the early diagnosis of endometriosis' painful symptoms, preventing its complications, and allowing an individualized treatment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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