Visible-Light-Induced Three-Component Tetrafluoroethyl-heteroarylation of Alkenes with 1,1,2,2-Tetrafluoroethanesulfonyl Chloride and Quinoxalin-2(1H)-ones.

Autor: Li X; Department of Chemistry, University of Florida, Gainesville, Florida, 32611, United States.; College of Chemistry and Chemical Engineering, Shandong University of Technology, 266 West Xincun Road, Zibo, 255000, China., Dolbier WR Jr; Department of Chemistry, University of Florida, Gainesville, Florida, 32611, United States.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Oct 09; Vol. 29 (56), pp. e202301814. Date of Electronic Publication: 2023 Sep 05.
DOI: 10.1002/chem.202301814
Abstrakt: 1,1,2,2-Tetrafluoroethyl-containing compounds are valuable structures due to their unique physicochemical properties, which have increasing potential application in drug discovery. However, synthetic methods for preparing such compounds are rare. Herein, we report the first use of 1,1,2,2-tetrafluoroethanesulfonyl chloride to introduce the HCF 2 CF 2 group into organic molecules via a three-component, radical tetrafluoroethyl-heteroarylation of alkenes with readily available quinoxalin-2(1H)-ones. This method provides a new and facile approach for late-stage functionalization of potential biologically active molecules.
(© 2023 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje