Head Orientation Modulates Vestibular Cerebellar Evoked Potentials (VsCEPs) and Reflexes Produced by Impulsive Mastoid and Midline Skull Stimulation.

Autor: Govender S; School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, 2052, Australia.; Neuroscience Research Australia, University of New South Wales, Randwick, Sydney, NSW, 2052, Australia., Hochstrasser D; MARCS Institute for Brain, Behaviour and Development, Western Sydney University, Westmead, Sydney, NSW, 2145, Australia., Todd NP; School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, 2052, Australia., Colebatch JG; School of Clinical Medicine, Randwick Clinical Campus, University of New South Wales, Sydney, NSW, 2052, Australia. j.colebatch@unsw.edu.au.; Neuroscience Research Australia, University of New South Wales, Randwick, Sydney, NSW, 2052, Australia. j.colebatch@unsw.edu.au.; Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, Sydney, NSW, 2031, Australia. j.colebatch@unsw.edu.au.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2024 Jun; Vol. 23 (3), pp. 957-972. Date of Electronic Publication: 2023 Jul 19.
DOI: 10.1007/s12311-023-01587-5
Abstrakt: The cerebellum plays a critical role in the modulation of vestibular reflexes, dependent on input from proprioceptive afferents. The mechanism of this cerebellar control is not well understood. In a sample of 11 healthy human subjects, we investigated the effects of head orientation on ocular, cervical, postural and cerebellar short latency potentials evoked by impulsive stimuli applied at both mastoids and midline skull sites. Subjects were instructed to lean backwards with the head positioned straight ahead or held rotated in different degrees of yaw towards the right and left sides. Impulsive mastoid stimulation, a potent method of utricular stimulation, produced localised vestibular cerebellar evoked potentials (VsCEPs: P12-N17) which were strongly modulated by head orientation. The response was larger on the side opposite to the direction of head rotation and with stimulation on the side of rotation. In contrast, ocular VEMPs (oVEMPs: n10-p16) were present but showed little change with head posture, while cervical VEMPs (cVEMPs: p15-n23) were larger with the head held rotated away from the side of the recording. Postural effects with lateral vestibular stimulation were strongly modulated by head rotation, with more powerful effects occurring bilaterally with stimulation on the side of rotation. The duration of the postural EMG changes was similar to the post-excitation inhibition of the electrocerebellogram (ECeG), consistent with cerebellar participation. We conclude that head rotation selectively affects evoked vestibular reflexes towards different targets, consistent with their physiological roles. Changes in VsCEPs may contribute to the modulation of postural reflexes by the cerebellum.
(© 2023. The Author(s).)
Databáze: MEDLINE
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