Tissue repair capacity of bioceramic endodontic sealers in rat subcutaneous tissue.

Autor: Santos GSBD; Post-Graduation Department, Universidade CEUMA, São Luis, Maranhão, Brazil., Carvalho CN; Post-Graduation Department, Universidade CEUMA, São Luis, Maranhão, Brazil., Tavares RRJ; Post-Graduation Department, Universidade CEUMA, São Luis, Maranhão, Brazil., Silva PGB; Christus University Center (Unichristus), Fortaleza, Ceará, Brazil., Candeiro GTM; Christus University Center (Unichristus), Fortaleza, Ceará, Brazil., Maia Filho EM; Post-Graduation Department, Universidade CEUMA, São Luis, Maranhão, Brazil.
Jazyk: angličtina
Zdroj: Brazilian dental journal [Braz Dent J] 2023 May-Jun; Vol. 34 (3), pp. 25-32.
DOI: 10.1590/0103-6440202305161
Abstrakt: This study aimed to evaluate the tissue repair capacity of four bioceramic endodontic sealers by quantifying type I and III collagen fibers. The following sealers were tested: EndoSequence BC Sealer (Brasseler, Brasseler, Savannah, USA), Bio C Sealer (Angelus, Londrina, Brazil), Bioroot RCS (Septodont, Santa Catarina, Brazil), and Sealer Plus BC (MKLife, Porto Alegre, Brazil). Polyethylene tubes 1.5 mm in diameter and 1 cm in length containing the endodontic sealers were implanted in the subcutaneous tissue of five rats (Rattus norvegicus albinus, Wistar lineage). After 14 days, the animals were euthanized, and collagen fibers were quantified from the histological tissue sections. Given a non-normal distribution of the data, a gamma regression with log link function was employed and implemented through the generalized linear models module, was used to test whether there was a significant difference between the sealers. The pairwise comparison was performed using Least significant difference. There were significant differences between the sealers for type I (p=0.001), type III (p=0.023), and total collagen (p=0.002). Overall, Bioroot sealer was statistically superior to the other sealers, except in the analysis of type III collagen, in which there was no difference between the Bioroot sealer and Bio C Sealer sealer and the control group (p>0.05). Bioroot RCS bioceramic endodontic sealer stimulates a greater production of collagen.
Databáze: MEDLINE