Sex differences in 123 I-mIBG scintigraphy imaging techniques in patients with heart failure.

Autor:	Conte M; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy., De Feo MS; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy., Frantellizzi V; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy., Di Rocco A; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy., Farcomeni A; Department of Economics & Finance, University of Rome 'Tor Vergata', Rome, Italy., De Cristofaro F; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy., Maria R; Nuclear Medicine Unit, Cardarelli Hospital, Campobasso, Italy., Pisani AR; Nuclear Medicine Department, University of Bari 'Aldo Moro', Bari, Italy., Rubini G; Nuclear Medicine Department, University of Bari 'Aldo Moro', Bari, Italy., De Vincentis G; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza, 'Sapienza' University of Rome, Rome Italy.
Jazyk:	angličtina
Zdroj:	Expert review of medical devices [Expert Rev Med Devices] 2023 Jul-Dec; Vol. 20 (9), pp. 769-778. Date of Electronic Publication: 2023 Jul 24.
DOI:	10.1080/17434440.2023.2239139
Abstrakt:	Background: 123 I-mIBG-scintigraphy could be a useful stratifying tool for patients with heart failure (HF). The purpose of this retrospective study is to evaluate whether there are differences between men and women with HF in terms of the prediction of cardiac arrhythmic events (AE). Research and Methods: A total of 306 patients, before implantable-cardioverter-defibrillator (ICD) implantation, were evaluated. They underwent 123 I-mIBG-scintigraphy and an evaluation of the results was performed after 85 months of follow-up. Early and late planar and SPECT cardiac images were acquired. Heart-to-mediastinum ratio (HM) for planar images and the sum of the segmental scores (SS) for SPECT were calculated. Results: In the general population, age, early SS (ESS), late SS (LSS), and ejection fraction (EF) were statistically significant for the prediction of AE at Cox regression, while early and late HM (eHM,lHM) were not significative for the prediction of AE. Population was divided into females and males and univariate analysis was conducted separately for the two cohorts: no significant variables for prediction of AE were found in females. For males, ESS, LSS, EF, and late HM were statistically significant predictors of AE. The overall survival was similar in males and females, but the risk of AE is lower in males than in females. Conclusions: 123 I-mIBG represents a more effective tool for the prediction of AE in male patients than in women.
Databáze:	MEDLINE
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