Short-term exposure to ambient air pollution and COVID-19 severity during SARS-CoV-2 Delta and Omicron waves: A multicenter study.

Autor: Poniedziałek B; Department of Environmental Medicine, Poznan University of Medical Sciences, Poznań, Poland., Rzymski P; Department of Environmental Medicine, Poznan University of Medical Sciences, Poznań, Poland.; Integrated Science Association (ISA), Universal Scientific Education and Research Network (USERN), Poznań, Poland., Zarębska-Michaluk D; Department of Infectious Diseases, Jan Kochanowski University, Kielce, Poland., Rogalska M; Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok, Poland., Rorat M; Department of Forensic Medicine, Wrocław Medical University, Wroclaw, Poland., Czupryna P; Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Bialystok, Poland., Kozielewicz D; Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland., Hawro M; Department of Infectious Diseases and Hepatology, Medical Center in Łańcut, Łańcut, Poland., Kowalska J; Department of Adult's Infectious Diseases, Hospital for Infectious Diseases, Medical University of Warsaw, Warsaw, Poland., Jaroszewicz J; Department of Infectious Diseases and Hepatology, Medical University of Silesia in Katowice, Bytom, Poland., Sikorska K; Division of Tropical Medicine and Epidemiology, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.; Division of Tropical and Parasitic Diseases, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland., Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok, Poland.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2023 Jul; Vol. 95 (7), pp. e28962.
DOI: 10.1002/jmv.28962
Abstrakt: Air pollution may affect the clinical course of respiratory diseases, including COVID-19. This study aimed to evaluate the relationship between exposure of adult patients to mean 24 h levels of particulate matter sized <10 μm (PM 10 ) and <2.5 μm (PM 2.5 ) and benzo(a)pyrene (B(a)P) during a week before their hospitalization due to SARS-CoV-2 infection and symptomatology, hyperinflammation, coagulopathy, the clinical course of disease, and outcome. The analyses were conducted during two pandemic waves: (i) dominated by highly pathogenic Delta variant (n = 1440) and (ii) clinically less-severe Omicron (n = 785), while the analyzed associations were adjusted for patient's age, BMI, gender, and comorbidities. The exposure to mean 24 h B(a)P exceeding the limits was associated with increased odds of fever and fatigue as early COVID-19 symptoms, hyperinflammation due to serum C-reactive protein >200 mg/L and interleukin-6 >100 pg/mL, coagulopathy due to  d-dimer >2 mg/L and fatal outcome. Elevated PM 10 and PM 2. 5 levels were associated with higher odds of respiratory symptoms, procalcitonin >0.25 ng/mL and interleukin >100 pg/mL, lower oxygen saturation, need for oxygen support, and death. The significant relationships between exposure to air pollutants and the course and outcomes of COVID-19 were observed during both pandemic waves. Short-term exposure to elevated PM and B(a)P levels can be associated with a worse clinical course of COVID-19 in patients requiring hospitalization and, ultimately, contribute to the health burden caused by SARS-CoV-2 variants of higher and lower clinical significance.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: