Clinical outcomes in cats with renal carcinoma undergoing nephrectomy: A retrospective study.

Autor: Kenny SA; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA., Cook MR; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA., Lenz JA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Maritato KC; MedVet Cincinnati, Cincinnati, Ohio, USA., Skorupski KA; Department of Surgical and Radiological Sciences, University of California at Davis, Davis, California, USA., Wustefeld-Janssens BG; Department of Clinical Sciences, Colorado State University College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado, USA., Pellin MA; Department of Clinical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA., Silveira CJ; Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA., Veytsman S; Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, Minnesota, USA., Selmic LE; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA., Husbands BD; Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, Ohio, USA.
Jazyk: angličtina
Zdroj: Veterinary and comparative oncology [Vet Comp Oncol] 2023 Dec; Vol. 21 (4), pp. 587-594. Date of Electronic Publication: 2023 Jul 19.
DOI: 10.1111/vco.12921
Abstrakt: Renal carcinomas (RC) are uncommonly encountered in feline medicine. Limited information regarding clinical presentation and postoperative outcomes is available. The purpose of this multi-institutional, retrospective study was to describe the presenting features and clinical outcomes of cats with RC undergoing nephrectomy. Thirty-six client-owned cats were included. Medical records from participating institutions were searched to identify cats that had a histopathologic diagnosis of RC and underwent nephrectomy from January 2001 to October 2021. The most common presenting complaints were weight loss (36.1%) and hyporexia (30.6%). Based on preoperative imaging and intraoperative findings, eight cats had suspected metastasis at the time of surgery (22.2%). Twenty-eight cats survived to discharge (77.8%). Median progression free interval (PFI) could not be determined, as only six cats developed suspected recurrence (16.7%) and seven cats developed suspected metastasis (19.4%). The all-cause median survival time (MST) was 203 days (95% confidence interval [CI]: 84, 1379 days). When cases that died prior to discharge were excluded, MST increased to 1217 days (95% CI: 127, 1641 days). One-year, two-year, and three-year survival rates were all 40.4%. Neither renal tumour histologic subtype nor the presence of preoperative azotemia, anaemia, erythrocytosis, haematuria, or suspected metastasis at diagnosis were found to influence survival. For cats surviving to discharge, prolonged survival times were possible. Further studies are necessary to elucidate other potential prognostic factors, the utility of postoperative adjuvant treatment, and to identify cats at-risk of mortality in the perioperative period.
(© 2023 The Authors. Veterinary and Comparative Oncology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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