Anti-Influenza Activity of Cetraria islandica Lichen Extracts in In Vitro Experiments.

Autor: Makarevich EV; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia. makarevich_ev@vector.nsc.ru., Filippova EI; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Sedel'nikova NV; Central Siberian Botanical Garden, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia., Mazurkov OY; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Protsenko MA; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Shishkina LN; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia., Mazurkova NA; State Research Center of Virology and Biotechnology 'VECTOR', Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Jun; Vol. 175 (2), pp. 215-218. Date of Electronic Publication: 2023 Jul 19.
DOI: 10.1007/s10517-023-05837-8
Abstrakt: The toxicity and antiviral activity of extracts obtained by the methods of aqueous and ethanol extraction of bioactive substances from Cetraria islandica lichen as a raw material were studied. Aqueous and ethanol extracts of lichen were characterized by low toxicity with respect to the passaged MDCK cell culture and exhibited antiviral activity. The ethanol extract showed more potent in vitro antiviral activity against human A/H3N2 and avian A/H5N1 influenza viruses: in a concentration of 50 μg/ml, it suppressed replication of these viruses by 3.5 and 4 log 10 , respectively, while the aqueous extract inhibited replication of viruses by 2 and 6 log 10 , respectively, when taken in a concentration of 500 μg/ml that was 10-fold higher than the concentration of the ethanol extract.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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