Multigenerational adversity impacts on human gut microbiome composition and socioemotional functioning in early childhood.

Autor:	Querdasi FR; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095., Enders C; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095., Karnani N; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore., Broekman B; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore., Yap Seng C; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo School of Medicine, National University of Singapore, Singapore 117597, Singapore., Gluckman PD; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore.; Liggins Institute, University of Auckland, Auckland 1023, New Zealand., Mary Daniel L; Duke-National University of Singapore Medical School, Singapore 169857, Singapore.; Department of Child Development, KK Women's and Children's Hospital, Singapore 229899, Singapore., Yap F; Department of Paediatrics, KK Women's and Children's Hopsital, Singapore 229899, Singapore.; Department of Pediatrics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore., Eriksson JG; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore.; Department of Obstetrics and Gynaecology, Yong Loo School of Medicine, National University of Singapore, Singapore 117597, Singapore.; Department of General Practice and Primary Health, University of Helsinki and Helsinki University Hospital, 00100 Helsinki, Finland.; Program of Public Health Research, Folkhälsan Research Center, 00250 Helsinki, Finland., Cai S; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore., Chong MF; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117561, Singapore., Toh JY; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore., Godfrey K; Department of Epidemiology, University of Southampton, Southampton SO16 6YD, United Kingdom.; Department of Human Development, University of Southampton, Southampton SO16 6YD, United Kingdom., Meaney MJ; Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore 138632, Singapore.; Department of Psychiatry, McGill University, Montreal, Quebec H3A 0G4, Canada.; Brain-Body Initiative, Agency for Science, Technology, and Research, Singapore 138632, Singapore., Callaghan BL; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 25; Vol. 120 (30), pp. e2213768120. Date of Electronic Publication: 2023 Jul 18.
DOI:	10.1073/pnas.2213768120
Abstrakt:	Adversity exposures in the prenatal and postnatal period are associated with an increased risk for psychopathology, which can be perpetuated across generations. Nonhuman animal research highlights the gut microbiome as a putative biological mechanism underlying such generational risks. In a sample of 450 mother-child dyads living in Singapore, we examined associations between three distinct adversity exposures experienced across two generations-maternal childhood maltreatment, maternal prenatal anxiety, and second-generation children's exposure to stressful life events-and the gut microbiome composition of second-generation children at 2 y of age. We found distinct differences in gut microbiome profiles linked to each adversity exposure, as well as some nonaffected microbiome features (e.g., beta diversity). Remarkably, some of the microbial taxa associated with concurrent and prospective child socioemotional functioning shared overlapping putative functions with those affected by adversity, suggesting that the intergenerational transmission of adversity may have a lasting impact on children's mental health via alterations to gut microbiome functions. Our findings open up a new avenue of research into the underlying mechanisms of intergenerational transmission of mental health risks and the potential of the gut microbiome as a target for intervention.
Databáze:	MEDLINE
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