Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer.

Autor: Pakkanen P; Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. pihla.pakkanen@helsinki.fi., Ilmarinen T; Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Halme E; Department of Otorhinolaryngology - Head and Neck Surgery, University of Tampere and Tampere University Hospital, Tampere, Finland., Irjala H; Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland., Koivunen P; Department of Otorhinolaryngology - Head and Neck Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland., Pukkila M; Department of Otorhinolaryngology - Head and Neck Surgery, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Ventelä S; Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku and Turku University Hospital, Turku, Finland., Almangush A; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Birkman EM; Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland., Lindgren O; Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland., Pohjolainen V; Fimlab Laboratories, Department of Pathology, Tampere University Hospital, Tampere, Finland., Sjöblom N; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Haglund C; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Hagström J; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Oral Pathology and Radiology, University of Turku, Turku, Finland., Aaltonen LM; Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2024 Aug; Vol. 485 (2), pp. 315-322. Date of Electronic Publication: 2023 Jul 18.
DOI: 10.1007/s00428-023-03586-7
Abstrakt: We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish university hospitals between 2003 and 2013 were included. Tissue microarray (TMA) blocks were used for PD-L1 immunohistochemistry. TILs were scored from intratumoral and stromal regions in whole tissue sections. Of 174 patients, 92 (53%) had negative, 66 (38%) intermediate, and 16 (9%) high PD-L1 levels. Of 80 patients whose TILs were analyzed, 50 (63%) had low and 30 (38%) high stromal TIL density. Patients with a local recurrence or a new primary tumor of the larynx had lower TIL density than had other patients (p = 0.047). High PD-L1 expression with low stromal TIL density was associated with inferior 5-year disease-specific survival (85% vs. 100%, p = 0.02). In conclusion, in patients treated for T1 glottic LSCC, low stromal TIL density was associated with local recurrences and new primary tumors of the larynx. High PD-L1 expression with low stromal TIL density may be associated with worse survival in T1 glottic LSCC.
(© 2023. The Author(s).)
Databáze: MEDLINE
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