Cross-talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39.

Autor: Hershfinkel M; Department of Physiology and Cell Biology and the School of Brain Sciences and Cognition, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Jazyk: angličtina
Zdroj: The Journal of physiology [J Physiol] 2024 Apr; Vol. 602 (8), pp. 1579-1594. Date of Electronic Publication: 2023 Jul 18.
DOI: 10.1113/JP283834
Abstrakt: Zinc is essential for many physiological functions, with a major role in digestive system, skin health, and learning and memory. On the cellular level, zinc is involved in cell proliferation and cell death. A selective zinc sensing receptor, ZnR/GPR39 is a Gq-coupled receptor that acts via the inositol trisphosphate pathway to release intracellular Ca 2+ . The ZnR/GPR39 serves as a mediator between extracellular changes in Zn 2+ concentration and cellular Ca 2+ signalling. This signalling pathway regulates ion transporters activity and thereby controls the formation of transepithelial gradients or neuronal membrane potential, which play a fundamental role in the physiological function of these tissues. This review focuses on the role of Ca 2+ signalling, and specifically ZnR/GPR39, with respect to the regulation of the Na + /H + exchanger, NHE1, and of the K + /Cl - cotransporters, KCC1-3, and also describes the physiological implications of this regulation.
(© 2023 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
Databáze: MEDLINE
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