| Autor: |
Alkhathami AG; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia., Abdullah MR; Al-Nisour University College, Baghdad, Iraq., Ahmed M; Medical Technical college, Al-Farahidi University, Iraq., Hassan Ahmed H; Department of Pharmacy, Al-Noor University College, Bartella, Iraq., Alwash SW; Medical Laboratory Techniques Department, Al-Mustaqbal University College, Babylon, Iraq Hillah., Muhammed Mahdi Z; Mazaya University College, Dhi-Qar, Nasiriyah, Iraq., Alsaikhan F; College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia., Dera AA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of drug targeting [J Drug Target] 2023 Aug; Vol. 31 (7), pp. 714-724. Date of Electronic Publication: 2023 Jul 19. |
| DOI: |
10.1080/1061186X.2023.2236330 |
| Abstrakt: |
Bone morphogenetic protein (BMP)-9 is considered a member of the transforming growth factor (TGF)β superfamily. It was first found as an inducer of bone and cartilage formation and then discovered that this factor mediates several physiologic functions and hemostasis. Besides physiological conditions, BMP9 has also been elucidated that it is involved in several pathological situations, especially cancer. In various cancers, dysregulation of BMP9 has raised the issue that BMP9 might play a conflicting role in tumour development. BMP9 binding to its receptors (BMPRs), including ALKs and BMPRII, induces canonical SMAD-dependent and non-canonical PI3K/AKT and MAPK signalling pathways in tumour cells. BMP9, via inducing apoptosis, inhibiting tumour-promoting cell signalling pathways, suppressing epithelial-mesenchymal transition (EMT) process, blocking angiogenesis, and preventing cross-talk in the tumour microenvironment, mainly exerts tumour-suppressive functions. In contrast, BMP9 triggers tumour-supportive signalling pathways, promotes EMT, and enhances angiogenesis, suggesting that BMP9 is also involved in tumour development. It has been demonstrated that modulating BMP9 expression and functions might be a promising approach to cancer treatment. It has also been indicated that evaluating BMP9 expression in cancers might be a biomarker for predicting cancer prognosis. Overall, BMP9 would provide a promising target in cancer management. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
