Association of Biochemical and Hematological Parameters With Enteric Fever Infection at the Dschang Regional Annex Hospital, Cameroon: A Cross-Sectional Study.
| Autor: | Etouke TAN; Department of Biochemistry, University of Dschang, Dschang, CMR., Ful Kuh G; Department of Biochemistry, University of Dschang, Dschang, CMR., Nzesseu VL; Department of Biochemistry, University of Dschang, Dschang, CMR., Gomseu BED; Department of Biochemistry, University of Dschang, Dschang, CMR., Tamokou JD; Department of Biochemistry, University of Dschang, Dschang, CMR., Dzoyem JP; Department of Biochemistry, University of Dschang, Dschang, CMR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Jun 16; Vol. 15 (6), pp. e40498. Date of Electronic Publication: 2023 Jun 16 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.40498 |
| Abstrakt: | Background Enteric fever is a systemic infection in humans caused by the Gram-negative bacilli Salmonella enterica serovars Typhi and Paratyphi . Although the diagnosis typically involves the isolation of Salmonella enterica serovars, it is often determined based on laboratory findings and clinical observations. However, due to the wide variety and the non-specific character of clinical features, making a definitive diagnosis presents numerous challenges. Therefore, the aim of this study was to find the predictive hematological and biochemical parameters which would serve in the diagnosis, prognosis, and treatment of typhoid fever cases. Methodology A cross-sectional study was conducted from November 2020 to September 2021 on1076consented volunteerparticipants. Stool culture and identification tests enabled us to distinguish three groups including 423 Salmonella Typhi positive patients, 115 S. Paratyphi positive patients, and 538 Salmonella negative participants. Biochemical and hematological parameters were evaluated using standard methods from commercial kits and Sysmex KX-21N automated hematology analyzer, respectively. A multiple logistic regression analysis was performed to identify the validity of the hematological and biochemical characteristics for enteric fever diagnosis. Results Multiple logistic regression showed hyper creatininemia, hypoalbuminemia, hyper total proteinemia, hyper alkaline phosphatase (ALP), hyper alanine aminotransferase (ALT), hyper total bilirubinemia, hyper conjugated bilirubinemia, hyper triglyceridemia, hyper C-reactive protein (CRP), leukopenia, thrombocytopenia, lymphopenia, monocytopenia, low hemoglobin, low hematocrit, low mean corpuscular volume (MCV), low mean corpuscular hemoglobin (MCH), low platelet, low platelet crit level, high platelet distribution width (PDW) level, high erythrocyte sedimentation rate 1 (ESR1) level as significant biological abnormalities associated (odds ratio {OR} > 1; p < 0.05) with enteric fever infection. Similarly, hyper ESR2 was an independent predictor (OR > 1; p < 0.05) of S. Typhi infection. However, a negative and significant association (OR < 1; p < 0.05) was recorded between enteric fever infection and high mean platelet volume (MPV). Conclusion Overall the results of the biochemical and hematological profiles can serve as potential diagnostic markers for typhoid fever. These markers can also be useful in the appropriate management of those with enteric fever, preventing severity and limiting outcomes of mortality. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Etouke et al.) |
| Databáze: | MEDLINE |
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