Long-term outcomes following surgical treatment for thymic epithelial tumor in Japan and an analysis of prognostic factors based on the Japanese Association for Research on the Thymus nationwide database.

Autor: Okumura M; Department of General Thoracic Surgery, National Hospital Organization (NHO), Osaka Toneyama Medical Center, 5-1-1 Toneyama, Toyonaka, Osaka, 560-8552, Japan. okumura.meinoshin.hy@mail.hosp.go.jp., Yoshino I; Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan., Funaki S; Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan., Okuda K; Department of Thoracic and Pediatric Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan., Watanabe SI; Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan., Tsuboi M; Division of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan., Shimizu K; Division of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan., Date H; Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan., Chen-Yoshikawa TF; Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan., Nakajima J; Department of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan., Toyooka S; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan., Asamura H; Division of Thoracic Surgery, Keio University School of Medicine, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Surgery today [Surg Today] 2023 Nov; Vol. 53 (11), pp. 1247-1259. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1007/s00595-023-02705-w
Abstrakt: Purpose: Patients with a thymic epithelial tumor (TET), comprising thymoma, thymic carcinoma (TC), and thymic neuroendocrine neoplasm (TNEN), are rarely encountered. The present study was conducted to determine the recent outcomes of surgical treatment for TET in Japan and clarify the significance of prognostic factors by analyzing a nationwide database created by the Japanese Association for Research on the Thymus (JART).
Methods: The JART database includes records of 2471 thymoma, 285 TC, and 56 TNEN cases surgically treated between 1991 and 2010. At the time of the final follow-up examination, 439 patients had died, with tumor the cause of death in 188. The disease-specific survival was examined using the Kaplan-Meier method, with Cox's proportional hazards model utilized to determine independent prognostic factors.
Results: The 10-year survival rate according to TNM-based Stage I, II, IIIA, IIIB, IVA, and IVB classification was 98.7%, 76.8%, 85.0%, 68.9%, 66.2%, and 59.8%, respectively. The T factor, M factor, and tumor size were independent prognostic factors in both thymoma and thymic carcinoma cases, while the N factor had tendency to be a prognostic factor in thymoma but not in thymic carcinoma cases. The WHO histological type was an independent factor in thymoma cases.
Conclusion: The significance of pathology and TNM classification as prognostic factors was confirmed.
(© 2023. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.)
Databáze: MEDLINE
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