Gallium-68 labelled RGD PET/CT imaging of endothelial activation in COVID-19 patients.

Autor: van Genugten EAJ; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands., van Lith TJ; Department of Neurology, Donders Center for Medical Neurosciences, Radboud University Medical Center, Nijmegen, The Netherlands., van den Heuvel FMA; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., van Steenis JL; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.; Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., Ten Heggeler RM; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands.; Faculty of Science and Technology, University of Twente, Enschede, The Netherlands., Brink M; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands., Rodwell L; Department of Health Evidence, Section Biostatistics, Radboud University Medical Center, Nijmegen, The Netherlands., Meijer FJA; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands., Lobeek D; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands., Hagmolen Of Ten Have W; Department of Respiratory Diseases, Radboud University Medical Center, Nijmegen, The Netherlands., van de Veerdonk FL; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Netea MG; Department of Respiratory Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany., Prokop M; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands., Nijveldt R; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands., Tuladhar AM; Department of Neurology, Donders Center for Medical Neurosciences, Radboud University Medical Center, Nijmegen, The Netherlands., Aarntzen EHJG; Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525GA, Nijmegen, The Netherlands. erik.aarntzen@radboudumc.nl.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jul 17; Vol. 13 (1), pp. 11507. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1038/s41598-023-37390-9
Abstrakt: In coronavirus disease 2019 (COVID-19), endothelial cells play a central role and an inadequate response is associated with vascular complications. PET imaging with gallium-68 labelled RGD-peptide ( 68 Ga-RGD) targets α v β 3 integrin expression which allows quantification of endothelial activation. In this single-center, prospective observational study, we included ten hospitalized patients with COVID-19 between October 2020 and January 2021. Patients underwent 68 Ga-RGD PET/CT followed by iodine mapping of lung parenchyma. CT-based segmentation of lung parenchyma, carotid arteries and myocardium was used to quantify tracer uptake by calculating standardized uptake values (SUV). Five non-COVID-19 patients were used as reference. The study population was 68.5 (IQR 52.0-74.5) years old, with median oxygen need of 3 l/min (IQR 0.9-4.0). 68 Ga-RGD uptake quantified as SUV ± SD was increased in lungs (0.99 ± 0.32 vs. 0.45 ± 0.18, p < 0.01) and myocardium (3.44 ± 1.59 vs. 0.65 ± 0.22, p < 0.01) of COVID-19 patients compared to reference but not in the carotid arteries. Iodine maps showed local variations in parenchymal perfusion but no correlation with SUV. In conclusion, using 68 Ga-RGD PET/CT in COVID-19 patients admitted with respiratory symptoms, we demonstrated increased endothelial activation in the lung parenchyma and myocardium. Our findings indicate the involvement of increased and localized endothelial cell activation in the cardiopulmonary system in COVID-19 patients.Trail registration: NCT04596943.
(© 2023. The Author(s).)
Databáze: MEDLINE
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