Ambient temperature, heat stress and fetal growth: A review of placenta-mediated mechanisms.

Autor: Cowell W; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Ard N; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA., Herrera T; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Medley EA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA., Trasande L; Department of Pediatrics, NYU Grossman School of Medicine, New York, NY, USA; Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA. Electronic address: leonardo.trasande@nyulangone.org.
Jazyk: angličtina
Zdroj: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2023 Oct 01; Vol. 576, pp. 112000. Date of Electronic Publication: 2023 Jul 17.
DOI: 10.1016/j.mce.2023.112000
Abstrakt: Pregnancy is increasingly considered a period of vulnerability for extreme heat exposure. Multiple lines of evidence support that heat stress is associated with placental insufficiency, poor fetal growth and decreased birth weight. In this narrative review, we first summarize evidence linking ambient temperature or experimentally-induced heat stress with fetal and placental growth outcomes in humans, ruminants and murine species. We then synthesize the literature on putative underlying biological pathways with a focus on the placenta. Reviewed mechanisms include: reduced uterine-placental blood flow, impaired supply of metabolic substrates to the fetus, activation of the maternal stress-response system, and disruption of other endocrine and immune system endpoints. Taken together, this body of evidence supports that exposure to extreme ambient heat likely has adverse consequences for placental development and function. However, research investigating placenta-mediated pathophysiological mechanisms in humans remains extremely limited.
Competing Interests: Declaration of competing interest None.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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