Comparison of the 8th edition of TNM staging of oral cancer with the 7th edition and its prognostic significance using clinical depth of invasion and extranodal extension.

Autor: Yokota Y; Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan., Hasegawa T; Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Yamakawa N; Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan., Rin S; Department of Clinical Oral Oncology, Hokkaido Cancer Center, Sapporo, Japan., Otsuru M; Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Yamada SI; Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan., Hirai E; Oral and Maxillofacial Surgery, Oita Red Cross Hospital, Oita, Japan., Ashikaga Y; Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan., Yamamoto K; Oral and Maxillofacial Surgery, Oita Red Cross Hospital, Oita, Japan., Ueda M; Department of Clinical Oral Oncology, Hokkaido Cancer Center, Sapporo, Japan., Kirita T; Department of Oral and Maxillofacial Surgery, Nara Medical University, Nara, Japan., Umeda M; Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan., Akashi M; Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Kurita H; Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan., Ohiro Y; Oral and Maxillofacial Surgery, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan., Yanamoto S; Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan., Okura M; Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, Osaka, Japan; Oral and Maxillofacial Surgery, Saiseikai Matsusaka General Hospital, Mie, Japan. Electronic address: mokuramokura@yahoo.co.jp.
Jazyk: angličtina
Zdroj: Oral oncology [Oral Oncol] 2023 Oct; Vol. 145, pp. 106519. Date of Electronic Publication: 2023 Jul 16.
DOI: 10.1016/j.oraloncology.2023.106519
Abstrakt: Objectives: The 8th edition of the International Union Against Cancer Control/American Joint Committee on Cancer Staging System introduced depth of invasion (DOI) and extranodal extension (ENE) into the staging of oral cavity cancer. We evaluated the prognostic ability of this new staging system compared with the 7th edition using clinical DOI (cDOI) and clinical ENE (cENE).
Materials and Methods: We retrospectively reviewed and restaged 2,118 patients with oral squamous cell carcinoma treated between 2001 and 2018 using cDOI and cENE. Overall and disease-specific survival were used as endpoints to compare the prognostic outcomes of the 7th and 8th editions using Harrell's concordance index (C-index).
Results: In total, 305 (14.4 %) cases were upstaged in the T category, 85 (4.0 %) cases were upstaged in the N category, and 280 (13.2 %) cases were upstaged in the overall TNM stage. The introduction of the cDOI increased the C-index and hazard ratio (HR) for each T category. The introduction of cENE increased the N3b category of 85 cases, bringing the total to 94 cases, thereby widening the differences between each N category. In the 8th edition, the C-index and HR for overall TNM stage increased, and the discrimination between stage groups improved.
Conclusions: The 8th edition of the TNM clinical staging system using cDOI and cENE predominantly identified patients with a high mortality rate, thus improving the ability to discriminate and prognosticate oral cancer.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: