| Autor: |
Sadaf F; Pharmcology Department, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan., Saleem R; Department of Chemistry, Jinnah University for Women, Karachi, Pakistan., Khan RA; Pharmaceutical Reserach Centre, PCSIR Laboratories Complex, Karachi, Pakistan., Ahmad U; Faculty of Medicine and Dentistry, Hamdard University, Karachi, Pakistan., Lubna; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, Pakistan., Bano S; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, Pakistan., Faizi S; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, Pakistan. |
| Abstrakt: |
The work is aimed to evaluate the blood pressure reducing effect of constituents from methanol extract and associated constituents of Tagetes patula flowers in normotensive and L-NAME induced hypertensive rats. The HPLC analysis of methanol extract of Tagetes patula flowers (JFM) resulted in the quantitative identification and percent comparison of four phenolic constituents, protocatechuic acid (PA), methyl protocatechuate (MPA), patulitrin (TRIN) and patuletin (PAT). All the extracts, fractions and compounds examined showed significant blood pressure lowering activity. Patulitrin (TRIN) which has emerged as the major constituent (15.33%) of T. patula flowers showed significant 30% and 68% fall in blood pressure in normotensive and L-NAME induced hypertensive rats respectively. The patuletin (PAT), which is an aglycone of TRIN displayed high percentage (84%) of antihypertensive activity. Further, comprehensive and advanced studies on these constituents may result in preparation of an effective blood pressure lowering medicine with active precious rare flavonoids, patuletin and patulitrin. |
