Efficacy of Isoflurane-Remifentanil versus Propofol-Remifentanil on Controlled Hypotension and Surgeon Satisfaction in Rhinoplasty: A Single-Blind Clinical Trial Study.

Autor: Dehghanpisheh L; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Sahmeddini MA; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Kaboodkhani R; Otolaryngology Research Center, Department of Otorhinolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran., Samadi K; Department of Anesthesiology, Shahid Dastgheib Hospital, Shiraz University of Medical Sciences, Shiraz, Iran., Khademi S; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Rafati Z; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Abbasi S; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Abbasi R; Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk: angličtina
Zdroj: Iranian journal of medical sciences [Iran J Med Sci] 2023 Jul; Vol. 48 (4), pp. 379-384.
DOI: 10.30476/IJMS.2022.94781.2608
Abstrakt: Background: Rhinoplasty is a complex but popular surgery in Iran. The main complications of the surgery are post-operative bleeding and nasal septal hematoma due to poor intra-operative controlled hypertension. This study aimed to compare the efficacy of isoflurane-remifentanil (I-R) versus propofol-remifentanil (P-R) to induce controlled hypotension and to assess surgeon satisfaction with each of these combinations during rhinoplasty.
Methods: In 2020-2021, a single-blind clinical study was conducted on 98 patients aged 18-50 years undergoing rhinoplasty at Mother and Child Hospital (Shiraz, Iran). Patients were randomly divided into P-R (n=48) and I-R (n=50) groups. Changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were assessed during surgery and in the recovery room. A questionnaire was used to evaluate the level of surgeon satisfaction. Data were analyzed using independent samples t test, Chi-square test, and repeated measures ANOVA with SPSS software. P<0.05 was considered statistically significant.
Results: Five minutes after anesthesia induction, the P-R combination had a greater effect on reducing SBP (P=0.010), DBP (P=0.007), MAP (P=0.003), and HR (P=0.026) than I-R. However, from the 40 th minute to the end of surgery and after 30 minutes of recovery, the I-R combination had a slightly better effect on blood pressure reduction than P-R. There was no difference in surgeon satisfaction with either of the two drug combinations.
Conclusion: Both P-R and I-R combinations are recommended to induce hypotension during rhinoplasty. However, I-R is more effective than P-R in inducing the desired controlled hypotension.
Competing Interests: None declared.
(Copyright: © Iranian Journal of Medical Sciences.)
Databáze: MEDLINE
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