The interactive effects of psychosocial stress and diet composition on health in primates.

Autor: Shively CA; Department of Pathology, Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA. Electronic address: cshively@wakehealth.edu., Frye BM; Department of Pathology, Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Biology, Emory and Henry College, Emory, VA, USA., Negrey JD; Department of Pathology, Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Johnson CSC; Department of Psychology, University of Washington, Seattle, WA, USA., Sutphen CL; Department of Pathology, Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Molina AJA; Department of Medicine, UCSD, San Diego, CA, USA., Yadav H; Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL, USA., Snyder-Mackler N; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; School for Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA., Register TC; Department of Pathology, Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2023 Sep; Vol. 152, pp. 105320. Date of Electronic Publication: 2023 Jul 13.
DOI: 10.1016/j.neubiorev.2023.105320
Abstrakt: Social disadvantage and diet composition independently impact myriad dimensions of health. They are closely entwined, as social disadvantage often yields poor diet quality, and may interact to fuel differential health outcomes. This paper reviews effects of psychosocial stress and diet composition on health in nonhuman primates and their implications for aging and human health. We examined the effects of social subordination stress and Mediterranean versus Western diet on multiple systems. We report that psychosocial stress and Western diet have independent and additive adverse effects on hypothalamic-pituitary-adrenal and autonomic nervous system reactivity to psychological stressors, brain structure, and ovarian function. Compared to the Mediterranean diet, the Western diet resulted in accelerated aging, nonalcoholic fatty liver disease, insulin resistance, gut microbial changes associated with increased disease risk, neuroinflammation, neuroanatomical perturbations, anxiety, and social isolation. This comprehensive, multisystem investigation lays the foundation for future investigations of the mechanistic underpinnings of psychosocial stress and diet effects on health, and advances the promise of the Mediterranean diet as a therapeutic intervention on psychosocial stress.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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