Management of short cervix in twin-to-twin transfusion syndrome: a role for pessary placement following fetoscopic laser surgery?

Autor: Bartin R; Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine, Université de Paris, Paris, France., Andrioli Peralta CF; Gestar Fetal Medicine and Surgery Center, São Paulo, Brazil; Brazilian Ministry of Health, Programa de Desenvolvimento Institucional do Sistema Único de Saúde, São Paulo, Brazil., Peneluppi Horak AC; Heart Hospital Research Institute, São Paulo, Brazil; Brazilian Ministry of Health, Programa de Desenvolvimento Institucional do Sistema Único de Saúde, São Paulo, Brazil., Rodrigues da Costa KJ; Heart Hospital Research Institute, São Paulo, Brazil; Brazilian Ministry of Health, Programa de Desenvolvimento Institucional do Sistema Único de Saúde, São Paulo, Brazil., Colmant C; Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France., Stirnemann J; Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine, Université de Paris, Paris, France., Ville Y; Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France; Faculté de Médecine, Université de Paris, Paris, France. Electronic address: ville.yves@gmail.com.
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2024 Jan; Vol. 230 (1), pp. 91.e1-91.e12. Date of Electronic Publication: 2023 Jul 13.
DOI: 10.1016/j.ajog.2023.07.014
Abstrakt: Background: Preterm labor and delivery is a major concern for patients with twin-to-twin transfusion syndrome undergoing fetoscopic laser surgery. A preoperative short cervix is a risk factor for preterm labor. Pessary placement is a short-acting intervention that may be useful to reduce this adverse event.
Objective: This study aimed to investigate the relationship between pessary placement and preterm delivery in monochorionic twin pregnancies with twin-to-twin transfusion syndrome and a short cervix before fetoscopic laser surgery.
Study Design: This was a retrospective study in 2 centers, including all pregnancies affected by twin-to-twin transfusion syndrome that underwent fetoscopic laser surgery with the Solomon technique between 2013 and 2022 (center A) and 2014 and 2022 (center B) with a preoperative cervical length below 25 mm. This study explored the correlation between cervical length and fetoscopic laser surgery-to-delivery interval following active or expectant management and compared perinatal outcomes between patients managed expectantly and patients managed with pessary placement, using multivariate analysis to control for potential confounders. Patients with a cervical length below 5 mm were not included in the comparative analysis.
Results: Of 685 patients, 134 met the inclusion criteria. Moreover, 21 patients were treated with a cervical cerclage and excluded from the analysis, leaving 113 patients for the final analysis. There was a significant negative correlation between cervical length at fetoscopic laser surgery and the risk of early delivery (adjusted odds ratio, 0.66; 95% confidence interval, 0.49-0.81; P<.001). The use of a pessary correlated with fewer patients delivering before 28 weeks of gestation (adjusted odds ratio, 0.28; 95% confidence interval, 0.09-0.75), fewer double neonatal demise (adjusted odds ratio, 0.2; 95% confidence interval, 0.05-0.75). Posthoc subgroup analysis suggested that these improvements were essentially noticeable for cervical lengths between 5 and 18 mm, where pessary placement was associated with an increased fetoscopic laser surgery-to-delivery interval (+24 days; 95% confidence interval, 0.86-42; P=.042) and later gestational age at delivery (+3.3 weeks; 95% confidence interval, 0.86-42; P=.035).
Conclusion: Patients with a moderately shortened cervix, between 5 and 18 mm, may benefit from pessary placement after fetoscopic surgery for twin-to-twin transfusion syndrome, resulting in a reduction of adverse neonatal outcomes, double neonatal demise, and severe preterm delivery.
(Copyright © 2023. Published by Elsevier Inc.)
Databáze: MEDLINE
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