Salivary Markers in Patients with Chronic Kidney Disease.

Autor: Poposki B; 1Department of Oral and Periodontal Diseases, Faculty of Dentistry - Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia., Ivanovski K; 1Department of Oral and Periodontal Diseases, Faculty of Dentistry - Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia., Stefanova R; 1Department of Oral and Periodontal Diseases, Faculty of Dentistry - Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia., Dirjanska K; 1Department of Oral and Periodontal Diseases, Faculty of Dentistry - Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia., Rambabova-Bushljetik I; 2University Clinic of Nephrology, Faculty of Medicine - Skopje, RN Macedonia., Ristovski V; 3Institute of Medical Physiology and Anthropology, Faculty of Medicine - Skopje, Ss. Cyril and Methodius University in Skopje, RN Macedonia., Risteska N; 4Clinic of Oral and Periodontal Diseases, PHO Dental Clinic Center St. Panteleimon, Skopje, RN Macedonia.
Jazyk: angličtina
Zdroj: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) [Pril (Makedon Akad Nauk Umet Odd Med Nauki)] 2023 Jul 15; Vol. 44 (2), pp. 139-147. Date of Electronic Publication: 2023 Jul 15 (Print Publication: 2023).
DOI: 10.2478/prilozi-2023-0033
Abstrakt: Aim of the study : To determine the possibility of using saliva as a diagnostic and prognostic tool for screening and monitoring kidney function. Methods : This study included 32 patients with different stages of chronic kidney disease (CKD) and 20 healthy examinees for the control group. Saliva was collected using the spitting method, and on the same day blood was also drawn from the examinees to determine serum concentrations of urea and creatinine. The salivary values of uric acid, urea, creatinine and albumin were determined with a spectrophotometer, as well as the serum concentrations of urea and creatinine. Results : Our results showed a statistically significant positive correlation between salivary and serum levels of urea and creatinine in patients with CKD (Pearson's correlation coefficient for urea was r =0.6527, p = 0.000, while for creatinine it was r = 0.5486, p = 0.001). We detected a statistically significant positive correlation between the salivary levels of urea and the clinical stage of CKD (r = 0.4667, p = 0.007). We did not register a significant correlation between the salivary levels of creatinine and the clinical stage of CKD (r = 0.1643, p = 0.369). Conclusion : Salivary urea is a valid marker for determining kidney function and a potential salivary marker for screening and monitoring kidney function. Salivary creatinine can be used as a qualitative marker, only indicating the existence of a disease.
(© 2023 Bojan Poposki et al., published by Sciendo.)
Databáze: MEDLINE
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