Arylacetonitrilases: Potential Biocatalysts for Green Chemistry.

Autor: Bhalla TC; Department of Biotechnology, Himachal Pradesh University, Himachal Pradesh, Gyan-Path, Shimla, 171005, India. bhallatc@rediffmail.com., Thakur N; Department of Biotechnology, Himachal Pradesh University, Himachal Pradesh, Gyan-Path, Shimla, 171005, India.; Department of Biotechnology and Microbiology, Himachal Pradesh, Rajkiya Kanya Mahavidyalaya, Longwood, Shimla, 171001, India., Kumar V; Department of Biotechnology, Himachal Pradesh University, Himachal Pradesh, Gyan-Path, Shimla, 171005, India.; Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
Jazyk: angličtina
Zdroj: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2024 Apr; Vol. 196 (4), pp. 1769-1785. Date of Electronic Publication: 2023 Jul 15.
DOI: 10.1007/s12010-023-04643-2
Abstrakt: Nitrilases are the enzymes that catalyze the hydrolysis of nitriles to corresponding carboxylic acid and ammonia. They are broadly categorized into aromatic, aliphatic, and arylacetonitrilases based on their substrate specificity. Most of the studies pertaining to these enzymes in the literature have focused on aromatic and aliphatic nitrilases. However, arylacetonitrilases have attracted the attention of academia and industry in the last several years due to their aryl specificity and enantioselectivity. They have emerged as interesting biocatalytic tools in green chemistry to synthesize useful aryl acids such as mandelic acid and derivatives of phenylacetic acid. The aim of the present review is to collate information on the arylacetonitrilases and their catalytic properties including enantioselectivity and potential applications in organic synthesis.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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