Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury.

Autor: Işik ÜG; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Ensari N; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Sarikçioğlu L; Anatomy Department, Mediterranean University, Antalya, Turkey., Sonbay Yilmaz ND; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Yüksel Y; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Senirli RT; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Yildiz M; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Selçuk ÖT; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Çetinkaya EA; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Eyigör H; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey., Gür ÖE; Otorhinolaryngology Department, Antalya Health Sciences University, Antalya, Turkey.
Jazyk: angličtina
Zdroj: Acta oto-laryngologica [Acta Otolaryngol] 2023 Jul-Aug; Vol. 143 (7), pp. 623-629. Date of Electronic Publication: 2023 Jul 15.
DOI: 10.1080/00016489.2023.2233085
Abstrakt: Background: Acute facial-nerve injury.
Objective: To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration.
Materials and Methods: Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks.
Results: The mean eye-closure movement score in Group B was significantly higher than that in Group F ( p  < .001). The mean whisker-movement score in Group B was significantly higher than that in Group F ( p  = .001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E ( p  < .001). Furthermore, an improvement in nerve ultrastructure was observed in Group B.
Conclusion: PRF application has a positive effect on nerve recovery after anastomosis.
Significance: Contribute to the literature to improve nerve regeneration.
Databáze: MEDLINE
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