Remodeling in Aortic Stenosis With Reduced and Preserved Ejection Fraction: Insight on Motion Abnormality Via 3D + Time Personalized LV Modeling in Cardiac MRI.

Autor: Chuah SH; Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia., Tan LK; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.; University Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Md Sari NA; Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Chan BT; Department of Mechanical, Materials and Manufacturing Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia., Hasikin K; Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia., Lim E; Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia., Ung NM; Clinical Oncology Unit, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Abdul Aziz YF; University Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Jayabalan J; Department of Biomedical Imaging, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia., Liew YM; Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2024 Apr; Vol. 59 (4), pp. 1242-1255. Date of Electronic Publication: 2023 Jul 15.
DOI: 10.1002/jmri.28915
Abstrakt: Background: Increased afterload in aortic stenosis (AS) induces left ventricle (LV) remodeling to preserve a normal ejection fraction. This compensatory response can become maladaptive and manifest with motion abnormality. It is a clinical challenge to identify contractile and relaxation dysfunction during early subclinical stage to prevent irreversible deterioration.
Purpose: To evaluate the changes of regional wall dynamics in 3D + time domain as remodeling progresses in AS.
Study Type: Retrospective.
Population: A total of 31 AS patients with reduced and preserved ejection fraction (14 AS_rEF: 7 male, 66.5 [7.8] years old; 17 AS_pEF: 12 male, 67.0 [6.0] years old) and 15 healthy (6 male, 61.0 [7.0] years old).
Field Strength/sequence: 1.5 T Magnetic resonance imaging/steady state free precession and late-gadolinium enhancement sequences.
Assessment: Individual LV models were reconstructed in 3D + time domain and motion metrics including wall thickening (TI), dyssynchrony index (DI), contraction rate (CR), and relaxation rate (RR) were automatically extracted and associated with the presence of scarring and remodeling.
Statistical Tests: Shapiro-Wilk: data normality; Kruskal-Wallis: significant difference (P < 0.05); ICC and CV: variability; Mann-Whitney: effect size.
Results: AS_rEF group shows distinct deterioration of cardiac motions compared to AS_pEF and healthy groups (TI AS_rEF : 0.92 [0.85] mm, TI AS_pEF : 5.13 [1.99] mm, TI healthy : 3.61 [1.09] mm, ES: 0.48-0.83; DI AS_rEF : 17.11 [7.89]%, DI AS_pEF : 6.39 [4.04]%, DI healthy : 5.71 [1.87]%, ES: 0.32-0.85; CR AS_rEF : 8.69 [6.11] mm/second, CR AS_pEF : 16.48 [6.70] mm/second, CR healthy : 10.82 [4.57] mm/second, ES: 0.29-0.60; RR AS_rEF : 8.45 [4.84] mm/second; RR AS_pEF : 13.49 [8.56] mm/second, RR healthy : 9.31 [2.48] mm/second, ES: 0.14-0.43). The difference in the motion metrics between healthy and AS_pEF groups were insignificant (P-value = 0.16-0.72). AS_rEF group was dominated by eccentric hypertrophy (47.1%) with concomitant scarring. Conversely, AS_pEF group was dominated by concentric remodeling and hypertrophy (71.4%), which could demonstrate hyperkinesia with slight wall dyssynchrony than healthy. Dysfunction of LV mechanics corresponded to the presence of myocardial scarring (54.9% in AS), which reverted the compensatory mechanisms initiated and performed by LV remodeling.
Data Conclusion: The proposed 3D + time modeling technique may distinguish regional motion abnormalities between AS_pEF, AS_rEF, and healthy cohorts, aiding clinical diagnosis and monitoring of AS progression. Subclinical myocardial dysfunction is evident in early AS despite of normal EF.
Level of Evidence: 4 TECHNICAL EFFICACY: Stage 1.
(© 2023 International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
Externí odkaz: