The cross-talk between LncRNAs and JAK-STAT signaling pathway in cancer.

Autor: Hjazi A; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia. Electronic address: a.hijazi@psau.edu.sa., Obaid RF; Department of Biomedical Engineering, Al-Mustaqbal University College, Babylon, Iraq. Electronic address: rasha20_12@yahoo.com., Ali SS; College of Dentistry, Al-Bayan University, Baghdad, Iraq. Electronic address: sally.saad@albayan.edu.iq., Abdullaev B; Department of Strategic Developement, Innovation and Research, New Uzbekistan University, 54 Mustaqillik Ave., Tashkent 100007, Uzbekistan; Senior researcher, Editory LLC, Tashkent 100050, Uzbekistan; Department of R&D, Independent Agency for Research Strategy, Tashkent 100050, Uzbekistan. Electronic address: b.abdullaev@newuzbekistanuniversity.uz., Alsaab HO; Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif 21944, Saudi Arabia. Electronic address: hashemalsaab@gmail.com., Huldani H; Department of Physiology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. Electronic address: huldani@gmail.com., Romero-Parra RM; Universidad Continental, Lima, Perú; Department of General Studies, University of Universidad Continental, Lima, Perú. Electronic address: rosarioromeroparra@gmail.com., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul 41001, Iraq. Electronic address: Dr.yassermustafa@uomosul.edu.iq., Hussien BM; Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq. Electronic address: mernamridha@gmail.com., Saadoon SJ; College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq. Electronic address: sarah.j.s@alayen.edu.iq.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2023 Aug; Vol. 248, pp. 154657. Date of Electronic Publication: 2023 Jul 01.
DOI: 10.1016/j.prp.2023.154657
Abstrakt: Long non-coding RNAs (lncRNAs) are non-coding RNAs that were transcribed from the human genome and have become important regulators in a number of cellular activities, mostly via controlling gene expression. A growing body of evidence shows that lncRNAs regulate various factors to impact various biological activities that are related to tumorigenesis, including the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. lncRNAs influence the JAK-STAT signaling pathway either by directly targeting or via indirectly modulating other upstream or downstream pathways' components like members of the suppressor of cytokine signaling (SOCS) family, and other genes that regulate cell proliferation, apoptosis, migration, invasion, and epithelial-mesenchymal transition. Furthermore, lncRNAs can act as downstream effectors of the JAK-STAT pathway and mediates tumorigenesis. The relationship between JAK-STAT signaling and lncRNAs differs among various types of cancers. Besides, lncRNAs, as biological molecules, have been shown to play a dual role in either tumorigenesis or tumor suppression in various cancers. In this review, we focus on the reciprocated regulation and functions of lncRNAs and the JAK-STAT signaling pathway in cancer, as well as narrate the latest research progress on this association. A deeper understanding of this correlation may simplify the recognition of potential targets for clinical therapeutics.
Competing Interests: Declaration of Competing Interest There is no conflict of interests.
(Copyright © 2023 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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