Stimuli-Responsive Delivery of Antimicrobial Peptides Using Polyelectrolyte Complexes.

Autor: Antropenko A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia., Caruso F; Department of Chemical Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia., Fernandez-Trillo P; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; Departamento de Química, Facultade de Ciencias and Centro de Investigacións Cientı́ficas Avanzadas (CICA), Universidade da Coruña, A Coruña, 15071, Spain.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2023 Nov; Vol. 23 (11), pp. e2300123. Date of Electronic Publication: 2023 Jul 24.
DOI: 10.1002/mabi.202300123
Abstrakt: Antimicrobial peptides (AMPs) are antibiotics with the potential to address antimicrobial resistance. However, their translation to the clinic is hampered by issues such as off-target toxicity and low stability in biological media. Stimuli-responsive delivery from polyelectrolyte complexes offers a simple avenue to address these limitations, wherein delivery is triggered by changes occurring during microbial infection. The review first provides an overview of pH-responsive delivery, which exploits the intrinsic pH-responsive nature of polyelectrolytes as a mechanism to deliver these antimicrobials. The examples included illustrate the challenges faced when developing these systems, in particular balancing antimicrobial efficacy and stability, and the potential of this approach to prepare switchable surfaces or nanoparticles for intracellular delivery. The review subsequently highlights the use of other stimuli associated with microbial infection, such as the expression of degrading enzymes or changes in temperature. Polyelectrolyte complexes with dual stimuli-response based on pH and temperature are also discussed. Finally, the review presents a summary and an outlook of the challenges and opportunities faced by this field. This review is expected to encourage researchers to develop stimuli-responsive polyelectrolyte complexes that increase the stability of AMPs while providing targeted delivery, and thereby facilitate the translation of these antimicrobials.
(© 2023 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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