Papaver rhoeas L. stem and flower extracts: Anti-struvite, anti-inflammatory, analgesic, and antidepressant activities.
| Autor: | Hmamou A; Laboratory of Engineering, Electrochemistry, Modeling and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796 Atlas, Fez 30000, Morocco., El-Assri EM; Laboratory of Biotechnology, Environment, Agri-Food and Health, Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, Fez, Morocco., El Khomsi M; Natural Resources and Sustainable Development Laboratory, Department of Biology, Faculty of Sci-ences, Ibn Tofail University, P.O. Box 133, Kenitra 14000, Morocco., Kara M; Laboratory of Biotechnology, Conservation and Valorisation of Natural Resources (LBCVNR), Department of Biology, Faculty of Science Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, B.P. 1796 Atlas, Fez 30000, Morocco., Zuhair Alshawwa S; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., Al Kamaly O; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia., El Oumari FE; Laboratory of Epidemiology and Research in Health Sciences, Faculty of Medicine and Pharmacy, Dental Medicine University of Sidi Mohammed Ben Abdellah, Fez 30070, Morocco., Eloutassi N; Laboratory of Engineering, Electrochemistry, Modeling and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796 Atlas, Fez 30000, Morocco., Lahkimi A; Laboratory of Engineering, Electrochemistry, Modeling and Environment, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, P.O. Box 1796 Atlas, Fez 30000, Morocco. |
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| Jazyk: | angličtina |
| Zdroj: | Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Aug; Vol. 31 (8), pp. 101686. Date of Electronic Publication: 2023 Jun 28. |
| DOI: | 10.1016/j.jsps.2023.06.019 |
| Abstrakt: | The Papaver rhoeas L. ( P. rhoeas ) plant, which belongs to the Papaveraceae family, is also used as food and is exploited to treat several health problems. The purpose of this research is to determine the anti-struvite, anti-inflammatory, analgesic, and antidepressant effects of the stem extract (SE) and flower extract (FE) of the plant P. rhoeas . We used polarizing microscopy and Fourier transform infrared spectrometry (FT-IR) to evaluate the anti-struvite effect of our plant. The edema approach induced by the carrageenan molecule was used to study the anti-inflammatory impact of our extracts. The analgesic test was determined by calculating the number of abdominal contractions induced by the intraperitoneal (IP) administration of acetic acid. To evaluate the antidepressant effect of our extracts, we used the forced swimming test (FST). According to the results of the secondary metabolite extraction, both extracts contained high contents of secondary metabolites, while the results of the screening test showed that flavonoids, alkaloids, phenols, tannins, coumarins, saponins, and terpenoids were present. The result of struvite crystallization inhibition observed by polarizing microscopy and FT-IR shows the inhibition of struvite crystal aggregation by SE by decreasing the amount and size of crystals in a manner similar to cystone. The results of anti-inflammatory activity show maximum inhibition of edema after six hours of carrageenan injection in rats (T Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).) |
| Databáze: | MEDLINE |
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