The Bacterial Spore as a Mucosal Vaccine Delivery System.

Autor: Saggese A; Department of Biology, Federico II University, 80126 Naples, Italy., Baccigalupi L; Department of Molecular Medicine and Medical Biotechnology, Federico II University, 80131 Naples, Italy., Donadio G; Department of Pharmacy, University of Salerno, 84084 Salerno, Italy., Ricca E; Department of Biology, Federico II University, 80126 Naples, Italy., Isticato R; Department of Biology, Federico II University, 80126 Naples, Italy.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 29; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 29.
DOI: 10.3390/ijms241310880
Abstrakt: The development of efficient mucosal vaccines is strongly dependent on the use of appropriate vectors. Various biological systems or synthetic nanoparticles have been proposed to display and deliver antigens to mucosal surfaces. The Bacillus spore, a metabolically quiescent and extremely resistant cell, has also been proposed as a mucosal vaccine delivery system and shown able to conjugate the advantages of live and synthetic systems. Several antigens have been displayed on the spore by either recombinant or non-recombinant approaches, and antigen-specific immune responses have been observed in animals immunized by the oral or nasal route. Here we review the use of the bacterial spore as a mucosal vaccine vehicle focusing on the advantages and drawbacks of using the spore and of the recombinant vs. non-recombinant approach to display antigens on the spore surface. An overview of the immune responses induced by antigen-displaying spores so far tested in animals is presented and discussed.
Databáze: MEDLINE
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