Cross-Kingdom Interaction of miRNAs and Gut Microbiota with Non-Invasive Diagnostic and Therapeutic Implications in Colorectal Cancer.

Autor: Pös O; Comenius University Science Park, 841 04 Bratislava, Slovakia.; Geneton Ltd., 841 04 Bratislava, Slovakia., Styk J; Comenius University Science Park, 841 04 Bratislava, Slovakia.; Geneton Ltd., 841 04 Bratislava, Slovakia.; Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia., Buglyó G; Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Zeman M; Comenius University Science Park, 841 04 Bratislava, Slovakia., Lukyova L; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, 842 05 Bratislava, Slovakia., Bernatova K; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, 842 05 Bratislava, Slovakia., Hrckova Turnova E; Comenius University Science Park, 841 04 Bratislava, Slovakia.; Slovgen Ltd., 841 04 Bratislava, Slovakia., Rendek T; Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia., Csók Á; Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Repiska V; Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.; Medirex Group Academy, n.p.o., 949 05 Nitra, Slovakia., Nagy B; Comenius University Science Park, 841 04 Bratislava, Slovakia.; Department of Human Genetics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary., Szemes T; Comenius University Science Park, 841 04 Bratislava, Slovakia.; Geneton Ltd., 841 04 Bratislava, Slovakia.; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, 842 05 Bratislava, Slovakia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 23; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 23.
DOI: 10.3390/ijms241310520
Abstrakt: Colorectal cancer (CRC) has one of the highest incidences among all types of malignant diseases, affecting millions of people worldwide. It shows slow progression, making it preventable. However, this is not the case due to shortcomings in its diagnostic and management procedure and a lack of effective non-invasive biomarkers for screening. Here, we discuss CRC-associated microRNAs (miRNAs) and gut microbial species with potential as CRC diagnostic and therapy biomarkers. We provide rich evidence of cross-kingdom miRNA-mediated interactions between the host and gut microbiome. miRNAs have emerged with the ability to shape the composition and dynamics of gut microbiota. Intestinal microbes can uptake miRNAs, which in turn influence microbial growth and provide the ability to regulate the abundance of various microbial species. In the context of CRC, targeting miRNAs could aid in manipulating the balance of the microbiota. Our findings suggest the need for correlation analysis between the composition of the gut microbiome and the miRNA expression profile.
Databáze: MEDLINE
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