Effect of COVID-19 Pandemic on Patients Who Have Undergone Liver Transplantation: Retrospective Cohort Study.

Autor: Akbulut S; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.; Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya 44280, Turkey.; Department of Public Health, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Yagin FH; Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Sahin TT; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Garzali IU; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.; Department of Surgery, Aminu Kano Teaching Hospital, Kano 700101, Nigeria., Tuncer A; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Akyuz M; Department of Surgical Nursing, Inonu University Faculty of Nursing, Malatya 44280, Turkey., Bagci N; Department of Surgical Nursing, Inonu University Faculty of Nursing, Malatya 44280, Turkey., Barut B; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Unsal S; Department of Nursing Service, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Sarici KB; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Saritas S; Department of Surgical Nursing, Inonu University Faculty of Nursing, Malatya 44280, Turkey., Ozer A; Department of Public Health, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Bentli R; Department of Internal Medicine, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Colak C; Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Bayindir Y; Department of Infectious Diseases and Clinical Microbiology, Inonu University Faculty of Medicine, Malatya 44280, Turkey., Yilmaz S; Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jul 03; Vol. 12 (13). Date of Electronic Publication: 2023 Jul 03.
DOI: 10.3390/jcm12134466
Abstrakt: Background: In liver transplant (LT) recipients, immunosuppressive therapy may potentially increase the risk of severe COVID-19 and may increase the mortality in patients. However, studies have shown conflicting results, with various studies reporting poor outcomes while the others show no difference between the LT recipients and healthy population. The aim of this study is to determine the impact of the COVID-19 pandemic on survival of LT recipients.
Methods: This is a retrospective cohort study analyzing the data from 387 LT recipients diagnosed with COVID-19. LT recipients were divided into two groups: survival ( n = 359) and non-survival ( n = 28) groups. A logistic regression model was used to determine the independent risk factors for mortality. Machine learning models were used to analyze the contribution of independent variables to the mortality in LT recipients.
Results: The COVID-19-related mortality rate in LT recipients was 7.2%. Multivariate analysis showed that everolimus use ( p = 0.012; OR = 6.2), need for intubation ( p = 0.001; OR = 38.4) and discontinuation of immunosuppressive therapy ( p = 0.047; OR = 7.3) were independent risk factors for mortality. Furthermore, COVID-19 vaccination reduced the risk of mortality by 100 fold and was the single independent factor determining the survival of the LT recipients.
Conclusion: The effect of COVID-19 infection on LT recipients is slightly different from the effect of the disease on the general population. The COVID-19-related mortality is lower than the general population and vaccination for COVID-19 significantly reduces the risk of mortality.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje