Comparison of Protein- or Amino Acid-Based Supplements in the Rehabilitation of Men with Severe Obesity: A Randomized Controlled Pilot Study.

Autor: Brunani A; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Cancello R; Obesity Unit, Department of Endocrine and Metabolic Diseases, Laboratory of Nutrition and Obesity Research, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy., Gobbi M; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Lucchetti E; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Di Guglielmo G; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Maestrini S; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Cattaldo S; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Piterà P; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Ruocco C; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, 20100 Milan, Italy., Milesi A; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy., Valerio A; Department of Molecular and Translational Medicine, University of Brescia, 25121 Brescia, Italy., Capodaglio P; IRCCS, Istituto Auxologico Italiano, Ospedale San Giuseppe, Piancavallo, 28921 Verbania, Italy.; Department of Surgical Sciences, Physical and Rehabilitation Medicine, University of Torino, 10121 Torino, Italy., Nisoli E; Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, 20100 Milan, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jun 25; Vol. 12 (13). Date of Electronic Publication: 2023 Jun 25.
DOI: 10.3390/jcm12134257
Abstrakt: Background: Weight loss is associated with a reduction in all body compartments, including muscle mass (MM), and this effect produces a decrease in function and muscle strength. Our objective was to assess the impact of protein or amino acid supplements on MM loss in middle-aged men (age < 65 years) with severe obesity (BMI > 35 kg/m 2 ) during weight loss.
Materials and Methods: We conducted a single-site randomized controlled trial (Clinicaltrials.gov NCT05143398) with 40 in-patient male subjects with severe obesity. Participants underwent an intervention program consisting of a low-calorie balanced diet and structured physical activity. They were randomly assigned to 4-week treatment groups: (1) control (CTR, N = 10), (2) protein (P, N = 10), (3) branched-chain amino acid (BCAA, N = 10), and (4) essential amino acid mixture with tricarboxylic acid cycle intermediates (PD-E07, N = 10) supplementation.
Results: Following 4 weeks of intervention, all groups showed similar reductions in body weight compared to baseline. When examining the delta values, a notable increase in muscle mass (MM) was observed in the PD-E07 intervention group [MM (kg): 2.84 ± 3.57; MM (%): 3.63 ± 3.14], in contrast to the CTR group [MM (kg): -2.46 ± 3.04; MM (%): -0.47 ± 2.28], with a statistical significance of p = 0.045 and p = 0.023, respectively. However, the MM values for the P group [MM (kg): -2.75 ± 5.98, p = 0.734; MM (%): -0.44 ± 4.02, p = 0.990] and the BCAA group [MM (kg): -1 ± 3.3, p = 0.734; MM (%): 0.34 ± 2.85, p = 0.956] did not exhibit a statistically significant difference when compared to the CTR group.
Conclusions: Amino acid-based supplements may effectively mitigate the loss of MM typically observed during weight reduction. Further validation through large-scale studies is necessary.
Databáze: MEDLINE
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