| Autor: |
Krokhicheva PA; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Goldberg MA; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Fomin AS; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Khayrutdinova DR; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Antonova OS; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Baikin AS; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Leonov AV; Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, Russia., Merzlyak EM; Department of Molecular Technologies, Pirogov Russian National Research Medical University, Moscow 117997, Russia., Mikheev IV; Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, Russia., Kirsanova VA; P.A. Hertsen Moscow Oncology Research Institute-Branch of National Medical Research Radiological Centre Affiliated with Ministry of Health of Russian Federation, 2nd Botkinsky Pr. 3, Moscow 125284, Russia., Sviridova IK; P.A. Hertsen Moscow Oncology Research Institute-Branch of National Medical Research Radiological Centre Affiliated with Ministry of Health of Russian Federation, 2nd Botkinsky Pr. 3, Moscow 125284, Russia., Akhmedova SA; P.A. Hertsen Moscow Oncology Research Institute-Branch of National Medical Research Radiological Centre Affiliated with Ministry of Health of Russian Federation, 2nd Botkinsky Pr. 3, Moscow 125284, Russia., Sergeeva NS; P.A. Hertsen Moscow Oncology Research Institute-Branch of National Medical Research Radiological Centre Affiliated with Ministry of Health of Russian Federation, 2nd Botkinsky Pr. 3, Moscow 125284, Russia., Barinov SM; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia., Komlev VS; A.A. Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow 119334, Russia. |
| Abstrakt: |
The development of magnesium calcium phosphate bone cements (MCPCs) has garnered substantial attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn 2+ at 0.5 and 1.0 wt.% were obtained and investigated. After mixing with a cement liquid, the structural and phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, and in vitro behavior of the cement materials were examined. A high compressive strength of 48 ± 5 MPa (mean ± SD) was achieved for the cement made from Zn 2+ 1.0 wt.%-substituted powders. Zn 2+ introduction led to antibacterial activity against Staphylococcus aureus and Escherichia coli strains, with an inhibition zone diameter of up to 8 mm. Biological assays confirmed that the developed cement is cytocompatible and promising as a potential bone substitute in reconstructive surgery. |
