Injectable multifunctional carboxymethyl chitosan/hyaluronic acid hydrogel for drug delivery systems.

Autor: Zhang F; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China., Zhang S; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China. Electronic address: zhangsufeng@sust.edu.cn., Lin R; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China., Cui S; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China., Jing X; Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science and Technology, Xi'an 710021, China., Coseri S; 'Petru Poni' Institute of Macromolecular Chemistry of Romanian Academy, 41 A Gr. Ghica Voda Alley, Iasi 700487, Romania.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Sep 30; Vol. 249, pp. 125801. Date of Electronic Publication: 2023 Jul 11.
DOI: 10.1016/j.ijbiomac.2023.125801
Abstrakt: Injectable hydrogels with notable mechanical properties and self-healing ability are promising carriers for use as a drug delivery system. Here, adipic acid dihydrazide (ADH) and calcium ions (Ca 2+ ) were introduced into quaternary ammonium carboxymethyl chitosan and aldehyde-modified hyaluronic acid hydrogels (QCS + OHA). The hydrogels were synthesized through the interaction of the Schiff bases (imine bonds, acylhydrazone bonds) and coordination bonds via a facile one-step approach. The gelation time (∼54 s) ensured excellent injectability. The QCS + OHA + ADH + Ca 2+ hydrogel had notable mechanical properties (compressive stress up to 896.30 KPa), good self-healing ability (up to 94 %), good pH responsiveness, and excellent antibacterial properties. In addition, the QCS + OHA + ADH + Ca 2+ hydrogel had a high drug loading capacity (121.3 mg/g) and sustained drug release behaviour (≥120 h). The results of cytotoxicity tests showed a high cell proliferation rate (up to 98 %) and good cytocompatibility. In summary, this work presents an injectable and self-healing pH-responsive hydrogel that can be used as a carrier for drug delivery systems.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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