In vitro toxicity and lung cancer risk: Atmospheric particulate matter from a city in southeastern Brazil impacted by biomass burning.

Autor: do Nascimento RKS; Chemistry Department, Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil., Carvalho JS; Chemistry Department, Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil., Miranda RR; Nanomedicine and Nanotoxicology Group, São Carlos Physics Institute, University of São Paulo, 13566-590, São Carlos, SP, Brazil., Lima MA; Chemistry Department, Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil., Rocha FV; Chemistry Department, Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil., Zucolotto V; Nanomedicine and Nanotoxicology Group, São Carlos Physics Institute, University of São Paulo, 13566-590, São Carlos, SP, Brazil., Lynch I; School of Geography, Earth and Environmental Sciences, University of Birmingham, B15 2TT, Birmingham, United Kingdom., Urban RC; Chemistry Department, Federal University of São Carlos, 13565-905, São Carlos, SP, Brazil; School of Geography, Earth and Environmental Sciences, University of Birmingham, B15 2TT, Birmingham, United Kingdom. Electronic address: roberta.urban@ufscar.br.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2023 Oct; Vol. 338, pp. 139484. Date of Electronic Publication: 2023 Jul 11.
DOI: 10.1016/j.chemosphere.2023.139484
Abstrakt: The effects of PM 10 on human health were investigated using samples collected in São Carlos city (São Paulo state), by the determination of the concentrations of PAHs and derivatives, together with evaluations of cytotoxicity and the formation of ROS in in vitro tests. In 2016, the mean concentrations of PM 10 , ΣPAHs, Σoxy-PAHs, Σnitro-PAHs, Σsaccharides, and Σions were 21.12 ± 9.90 μg m -3 , 1.47 ± 1.70 ng m -3 , 0.37 ± 0.31 ng m -3 , 0.84 ng m -3 , 119.91 ± 62.14 ng m -3 , and 5.66 ± 4.52 μg m -3 , respectively. The PM 10 concentrations did not exceed the limit thresholds set by national legislation, however, the annual lung cancer risk calculated was 2.59 ± 1.22 cases per 100,000 people, in the dry season, which accounts for the annual risk (April to September). Moreover, the carcinogenic activities of the PAHs mixture were more than 1000-fold higher in the dry season (dry season: BaP eq  = 0.30 ng m -3 ; wet season BaP eq  = 0.02 ng m -3 ). The concentrations of most analytes were also higher during the dry season, as had already been demonstrated in the same city. This was due to reductions in precipitation, relative humidity and air temperature, and increased biomass burning, which was the main source of PM 10 in the city in 2016 (contribution rate of more than 50%). Toxicological results also showed the negative impacts of PM 10 , exposure to PM 10 extracts for 72 h reduced the viability of A549 and MRC5 cells, and the formation of ROS was observed. The cellular responses obtained using combined and individual extracts of PM 10 differed and were sometimes associated with specific compounds. These demonstrate the importance of monitoring PM toxicity using different approaches and the main anthropogenic sources' contribution. Therefore, to improve air quality and human health, existing legislation needs to be modified to incorporate these tests.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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