A rare incidence of mandibular metastasis of papillary thyroid carcinoma: A case report and review of literature.

Autor: Raffaelli SD; Attending Physician, Department of Oral and Maxillofacial Surgery, United States Navy, Virginia Beach, VA 23451, United States of America. Electronic address: samuel.d.raffaelli.mil@health.mil., Shupak RP; Assistant Professor - Geisinger Commonwealth School of Medicine, Department of Oral Medicine and Maxillofacial Surgery, Geisinger Health System, Danville, PA 17821, United States of America., Winstead M; Assistant Professor, Department of Oral & Maxillofacial Surgery, University of Tennessee Health Science Center, Knoxville, TN 37920, United States of America., Hockaday JJ; Physician's Associate, Division of Maxillofacial Oncologic Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, John Peter Smith Health Network, Fort Worth, TX 76104, United States of America., Kim RY; Director of Research & Co Fellowship Director, Division of Maxillofacial Oncologic Reconstructive Surgery, Department of Oral and Maxillofacial Surgery, John Peter Smith Health Network, Fort Worth, TX 76104, United States of America.
Jazyk: angličtina
Zdroj: Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2023 Dec; Vol. 124 (6S), pp. 101560. Date of Electronic Publication: 2023 Jul 11.
DOI: 10.1016/j.jormas.2023.101560
Abstrakt: Papillary Thyroid Carcinoma (PTC) primarily metastasizes via regional lymphatics making its spread to the oral cavity exceedingly rare. Although this disease remains the most common endocrine malignancy, comprising roughly 85%-90% of all thyroid cancers, its occurrence within the oral cavity happens in less than 1% of oral malignancies. This study identifies a case involving a 77-year-old male with a history of well-differentiated PTC that was initially treated with a total thyroidectomy and adjuvant radioactive iodine. Five years after his initial treatment, surveillance imaging demonstrated a 3 cm expansile mass of the left mandible. An incisional biopsy then confirmed the diagnosis of metastatic PTC. A segmental resection of his mandible was completed with final reconstruction utilizing a fibula free flap. Given the limited number of cases involving metastatic spread of PTC to the oral cavity, a standardized treatment algorithm does not exist. Thus, this case serves to provide a documented report of this rare occurrence and to review literature that may help other clinicians treat patients with this malignancy type. There remains a need for future studies to create risk stratification models for patients with metastatic PTC that consider margin analysis, genetic characteristics, and risk factors to tailor individual treatment plans.
Competing Interests: Declaration of Competing Interest All authors confirm they have no competing interests in the publication of this paper.
(Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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