Cardiometabolic syndrome among general adult population in Ghana: The role of lipid accumulation product, waist circumference-triglyceride index, and triglyceride-glucose index as surrogate indicators.

Autor: Anto EO; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.; School of Medical and Health Sciences Edith Cowan University Perth Australia., Frimpong J; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Boadu WIO; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Korsah EE; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Tamakloe VCKT; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Ansah E; Department of Medical Diagnostics, Faculty of Allied Health Sciences, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Opoku S; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Acheampong E; School of Medical and Health Sciences Edith Cowan University Perth Australia.; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Asamoah EA; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Nyarkoa P; Department of Physiology, School of Medicine and Dentistry, College of Health Science Kwame Nkrumah University of Science and Technology Kumasi Ghana., Adua E; Rural Clinical School, Medicine and Health University of New South Wales Sydney New South Wales Australia., Afrifa-Yamoah E; School of Science Edith Cowan University Joondalup Australia., Annani-Akollor ME; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana., Obirikorang C; Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2023 Jul 11; Vol. 6 (7), pp. e1419. Date of Electronic Publication: 2023 Jul 11 (Print Publication: 2023).
DOI: 10.1002/hsr2.1419
Abstrakt: Background: Visceral obesity and insulin resistance contribute to developing cardiometabolic syndrome (MetS). We investigated the predictive abilities of lipid accumulation product (LAP), waist circumference-triglyceride index (WTI), and triglyceride-glucose (TyG) index for MetS screening among the general Ghanaian adults.
Methods: The final prospective analysis included 4740 healthy adults aged 30-90 years from three communities comprising Ejisu, Konongo, and Ashanti Akim Agogo in Ghana. Self-structured questionnaire pretested was used to collect sociodemographic, anthropometric, and clinical data. Blood samples were taken after fasting to measure glucose and lipid levels. LAP, WTI, and TyG were calculated from standard equations. MetS was defined by the International Diabetes Federation criteria. Receiver operating characteristic (ROC) curves and multivariable logistic regression were utilized to evaluate the potential of the three indices in identifying MetS.
Results: Of the 4740 participants, 39.7% had MetS. MetS was more common in females (50.3%) than in males (22.2%). Overall, LAP ≥ 27.52 yielded as the best index for MetS with the highest area under the ROC curve (AUC) (0.866). At cut-off LAP point of ≥23.87 in males and ≥33.32 in females, an AUC of 0.951 and 0.790 was identified in MetS prediction, respectively. LAP was an independent risk measure of MetS for both males (45.6-fold) and females (3.7-fold) whereas TyG was an independent risk measure for females (3.7-fold) only.
Conclusions: MetS is increasing among the general adult population. LAP and TyG are important sex-specific risk measures to screen for MetS among the general adult population in our cohort.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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